Efek Daun Etlingera hemisphaerica pada Perbaikan Skoring Spermatogenesis Tikus Putih (Rattus norvegicus) yang Diinduksi HgCl2

Abstract

This study aims to determine the effect of administration of Etlingera hemispharica leaf extract on white rats (Rattus norvegicus) induced by mercury chloride as seen from the histopathological description of the testes. The research method used is experimental post-test-only control group design. The extract was administered for seven days by gavage. Testicular organ harvesting was carried out on the 9th day after the rats were euthanized and continued with making testicular preparations. Testicular damage was assessed using the Johnsen score. Data were analyzed using non-parametric statistical tests. The results showed that the test groups had a p-value of 0.000. The histopathological description of the testes induced by HgCl2 had a p-value of 0.005 and the administration of E. hemisphaerica leaf extract in HgCl2-induced mice showed a p-value of 0.008. In conclusion, administration of E. hemisphaerica leaf extract to R. norvegicus induced by mercury chloride improved spermatogenesis on the histopathological features of the R. norvegicus testes.
 Keywords: Etlingera hemispharica, HgCl2, Johnsen Score, Rattus norvegicus

Etlingera (Zingiberaceae) in Bogor Botanic Gardens: Potential Benefits and Its Conservation Status

“…According to Ruyani et al (2018) and Umar et al (2021), the leaf extract of E. hemisphaerica contains tannins, saponins, alkaloids, flavonoids, antioxidants, minerals, and vitamin C. The leaves are used for wound cleansing, as an antibacterial agent against Staphylococcus aureus and Bacillus cereus, as an immunomodulator or immunostimulant, have a protective effect against HgCl2 toxicity, can improve the evaluation of the stage of spermatogenesis, and potentially lower blood glucose and triglyceride levels (Ruyani et al, 2014;Gresinta, 2019;Noverita and Sinaga, 2021). In addition, E. hemisphaerica has sour flowers, and the fruit has a fragrant smell to treat skin problems, cancer, and tumors.…”