Efeitos microscópicos do ácido acetilsalicílico (aspirina) e do acetaminofeno (tylenol) na movimentação dentária induzida e nas reabsorções radiculares associadas

Abstract

Maldonado,VB. Microscopic effects of Acetylsalicylic Acid (Aspirin) and Acetaminophen (Tylenol) on induced dental movement and root resorption associated [Dissertação]. Ribeirão Preto: FORP-Universidade de São Paulo; 2009. This study aimed at analysing the influence of acetylsalicylic acid and acetaminophen on induced dental movement and associated root resorption at cell and tissue levels by means of optic microscopy. The experimental groups consisted of 18 rats receiving physiological saline solution; 36 rats receiving acetylsalicylic acid; and 36 receiving acetaminophen. The animals were subdivided according to the duration of induced dental movement during treatment: 5, 7, and 9 days. The orthodontic appliance was conceived by Heller and Nanda and then modified by Martins-Ortiz. The drugs were administered during short and long periods of time. Quantitative histomorphometric microscopic analysis of the distal buccal root of the upper left first molar was performed in two steps: percentage quantification of hyaline areas of periodontal ligaments and percentage quantification of root resorption on pressure side. The results of the Student t test allow us to find the following: administration of acetylsalicylic acid and paracetamol compared to control group did not change the percentage amount of hyaline areas and root resorption for the three periods of time, regardless of the administration frequency. Long-administration versus short administration of acetylsalicylic acid as well as long-administration versus short administration of paracetamol did not change the percentage amount of hyaline areas and root resorptions for the three periods of study; one can conclude that there was no difference in the percentage amount of hyaline areas and root resorptions during the experimental periods in which acetylsalicylic acid and paracetamol were administered in all forms. By extrapolation, one can state that the use of acetylsalicylic acid acetaminophen following activation of orthodontic appliance for controlling pain and discomfort in patients does not affect dental movement nor influence frequency and severity of associated dental resorption.

Effects of medications and laser on induced tooth movement and associated root resorption: four key points

“…In 2009, Fracalossi et al 6 suggested a standardization of cross-sectional cuts of murine molars for the analysis of phenomena associated with induced tooth movement, and Santamaria Jr 22 described a practical way to quantify it. Still in 2009, Maldonado 19 investigated the effect of medications, particularly analgesic and anti-inflammatory drugs, on induced tooth movement and the frequency and severity of associated induced tooth movement.…”

Origem das controvérsias sobre os analgésicos após a ativação dos aparelhos ortodônticos: ácido acetilsalicílico ou acetaminofeno?

“…Based on reports found in the literature and the behavior of orthodontic clinical cases within the framework advanced by Maldonado 34 the authors developed the following hypothesis:…”

“…3,18 When administered to control pain and discomfort after activation of the orthodontic appliance, what would be the influence of ASA and acetaminophen on tooth movement and the root resorption associated with it? To help in clarifying this question, Maldonado 34 and his team set out to quantitatively determine the influence of ASA and acetaminophen on induced tooth movement and on root resorption by means of optical microscopy. In another study they described the history and action mechanisms of these two medications.…”

Evidence on the use of aspirin in the primary prevention of cardiovascular diseases Evidências sobre o uso de aspirina na prevenção primária de doenças cardiovasculares

“…It is an oral administration drug, intestinal absorption, rapid distribution, with half-life of 4 hours, metabolized in the liver and excreted by the renal route. 6 Only in 1939 was it approved by the Food and Drug Administration (FDA), being considered prototype and compared to all other non-steroidal anti-inflammatory drugs (NSAIDs). It is part of this group of drugs that act by inhibiting cyclooxygenase (COX) enzymes, causing a reduction in the synthesis of prostaglandins, which results in desirable and undesirable clinical-pharmacological events.…”