Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos.

Medeiros, Aldo da Cunha; Azevedo, Ítalo Medeiros; Lima, M. L. F.; Filho, Irami Araújo; Moreira, Marília Daniela Ferreira de Carvalho

doi:10.1590/0100-6991e-20181968

Cited by 14 publications

(7 citation statements)

References 29 publications

(12 reference statements)

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“…ATV treatment improved the structural integrity of ileal mucosa, indicating its bene cial role in in ammation. Similar results were found in other studies that assessed the activity of statins in mucositis and colitis, demonstrating an enteroprotective role for the gastrointestinal mucosa (25,44,48,49).…”

Section: Discussionsupporting

confidence: 89%

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Atorvastatin improves intestinal mucositis induced by 5-fluorouracil in mice by modulating the and epithelial barrier and inflammatory signaling pathways

Vital

Pires

Gallotti

et al. 2023

Preprint

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Chemotherapy-induced intestinal mucositis is a major side effect of cancer treatment. Statins are 3-hydroxy-3-methyl glutaryl coenzyme reductase inhibitors used to treat hypercholesterolemia and atherosclerotic diseases. Recent studies have demonstrated that atorvastatin (ATV) has antioxidant, anti-inflammatory, and resulting from the regulation of different molecular pathways. In the present study, we investigated the effects of ATV on intestinal homeostasis in 5-fluorouracil (5-FU)-induced mucositis. Our results showed that ATV protected the intestinal mucosa from epithelial damage caused by 5-FU mainly due to inflammatory infiltrate and intestinal permeability reduction, downregulation of inflammatory markers, such as Tlr4, MyD88, NF-κB, Tnf-a, Il1β, and Il6 dose-dependent. ATV also improved epithelial barrier function by upregulating the mRNA transcript levels of mucin 2 (MUC2), and ZO-1 and occludin tight junction proteins. The results suggest that the ATV anti-inflammatory and protective effects on 5-FU-induced mice mucositis involve the inhibition of the TLR4/MYD88/NPRL3/NF-κB, iNos, and caspase 3 signaling pathways.

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Section: Discussionsupporting

confidence: 89%

“…However, the ATV treatment did not signi cantly improve these outcomes. Similarly, Medeiros and coworkers (44) did not observe a reduction in body mass loss following simvastatin treatment in a 5-FUinduced mucositis model.…”

Section: Discussionmentioning

confidence: 78%

Atorvastatin improves intestinal mucositis induced by 5-fluorouracil in mice by modulating the and epithelial barrier and inflammatory signaling pathways

Vital

Pires

Gallotti

et al. 2023

Preprint

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“…Oral and gastrointestinal mucositis are the most common adverse effects of cancer chemotherapy [1,2]. Intestinal mucositis, characterized by inflammatory and/or ulcerative process in the gastrointestinal tract, is a result of cellular and tissue damage caused by 5-fluorouracil antimetabolite treatment [3].…”

Section: Introductionmentioning

confidence: 99%

Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway

et al. 2020

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Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from Dimorphandra gardneriana, has been reported as a potent antioxidant and anti-inflammatory agent. In the present study, we aimed to evaluate the effect of TRX on 5-FU-induced intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, TRX-50, TRX-100, TRX-150, Celecoxib (CLX), and CLX + TRX-100. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), mast and goblet cell counts, immunohistochemical analysis, and cyclooxygenase-2 (COX-2) activity. Compared to the saline treatment, the 5-FU treatment induced intense weight loss and reduction in villus height. TRX treatment (100 mg/kg) prevented the 5-FU-induced histopathological changes and decreased oxidative stress by decreasing the MDA levels and increasing GSH concentration. TRX attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. TRX also reversed the depletion of goblet cells. Our findings suggest that TRX at a concentration of 100 mg/kg had chemopreventive effects on 5-FU-induced intestinal mucositis via COX-2 pathway.

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“…Esta formulación se estudió en hámsteres, que tenían MO inducida por el fluorouracilo quimioterapéutico. Esta quimioterapia se considera un fármaco eficaz en el tratamiento del cáncer porque se integra con el ADN e interfiere en la síntesis o se incorpora a una nueva molécula, es decir, tiene acción anticancerígena, por lo que se vuelve citotóxica y daña las células presentes en el cuerpo humano (27) .…”

Section: Discussionunclassified

Efeito da Chamomilla Recutita no paciente oncológico com mucosite oral: revisão sistemática

Silva

Ramos

Schirmer³

et al. 2021

Enf Global

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Objetivo: Identificar los efectos de Chamomilla recutita (CR) a través de la literatura nacional e internacional.Método: Optamos por una revisión sistemática que incluía el análisis riguroso de los artículos, siendo extremadamente confiable y de gran importancia para los investigadores. Los artículos analizados se estudiaron cuidadosamente, de modo que hubo una recopilación de datos sobre los posibles efectos beneficiosos de la planta en cuestión, además del intento de determinar el método y la cantidad necesaria para que se pudiera obtener una aplicación terapéutica correcta en los portadores de este efecto secundario. Al final de la selección de estudios definidos por los criterios establecidos, se aplicaron nuevos instrumentos para validarlos, donde se llegó a una serie de estudios que fueron de máxima relevancia para la presente revisión.Resultados: Con el análisis de los estudios, se encontró CR en forma de enjuagues bucales, pomadas, tinturas e infusiones, todos con diferentes formas de concentración, preparación y uso. Con los análisis realizados, se encontró que la CR tiene un efecto terapéutico potencial en la práctica clínica con pacientes oncológicos y hematológicos, ya que proporciona amplios beneficios para esta población.Conclusión: Las formas de usar la CR demostraron ser efectivas, sin embargo, el método de enjuague e infusión fueron los estudios que más demostraron efectos beneficiosos para sus pacientes, a pesar de que todos mostraron efectividad. Se sugiere que los estudios futuros incluyan este método en la práctica clínica de los proveedores de servicios, para beneficiar a sus usuarios. Objective: To identify through national and international literature the effects of Chamomilla recutita (CR).Method: A systematic review was chosen which included rigorous analysis of articles, being extremely reliable and of great importance for researchers. The articles analyzed were carefully studied in order to collect data on the potential beneficial effects of the plant in question, in addition to the attempt to verify which method and quantity was necessary to obtain a correct therapeutic application in those with this side effect. At the end of the selection of studies defined by the established criteria, new instruments were applied to validate them, where a quantity of researches that were of entire relevance for this review was reached.Results: With the analysis of the studies, CR was found in the form of mouth rinses, ointments, tinctures and infusions, all with different forms of concentration, preparation and use. The analysis showed that CR presents a potential therapeutic effect in clinical practice with oncologic and hematologic patients, because it provides ample benefits to this population.Conclusion: The ways of using CR showed to be effective, however, the method of rinsing and infusion were the studies that most demonstrate beneficial effects to their patients, although all showed effectiveness. It is suggested future studies to insert this method in the clinical practice of service providers, in order to benefit its users. Objetivo: Identificar através da literatura nacional e internacional os efeitos da Chamomilla recutita (CR). Método: Optou-se por uma revisão sistemática que incluiu a análise rigorosa de artigos, sendo extremamente confiável e de grande importância para pesquisadores. Os artigos analisados foram criteriosamente estudados, para que houvesse uma coleta de dados sobre os potenciais efeitos benéficos da planta em questão, além da tentativa de constatar qual o método e a quantidade necessária para que se pudesse obter uma correta aplicação terapêutica nos portadores deste efeito colateral. Ao final da seleção dos estudos definidos pelos critérios estabelecidos, aplicou-se novos instrumentos para validação deles, onde se chegou a uma quantidade de pesquisas que eram de inteira relevância para a presente revisão. Resultados: Com a análise dos estudos, foi encontrado a CR em forma de enxaguatórios bucais, pomadas, tinturas e infusões, todas com diferentes formas de concentração, preparação e uso. Constatou-se com as análises realizadas, que a CR apresenta um potencial efeito terapêutico na prática clínica com pacientes oncológicos e hematológicos, pois proporciona amplos benefícios para esta população. Conclusão: As formas de utilização da CR mostraram-se eficazes, entretanto, o método de enxaguante e infusão foram os estudos que mais demonstram efeitos benéficos aos seus pacientes, apesar de todos demonstrarem eficácia. Sugere-se estudos futuros para que haja inserção deste método na prática clínica dos prestadores de serviços, a fim de beneficiar seus usuários.

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Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos.

Cited by 14 publications

References 29 publications

Atorvastatin improves intestinal mucositis induced by 5-fluorouracil in mice by modulating the and epithelial barrier and inflammatory signaling pathways

Atorvastatin improves intestinal mucositis induced by 5-fluorouracil in mice by modulating the and epithelial barrier and inflammatory signaling pathways

Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway

Efeito da Chamomilla Recutita no paciente oncológico com mucosite oral: revisão sistemática

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