Abstract:The utilization of dentifrices with low fluorine concentration, for children under 6 years of age, has been suggested to reduce the risks of dental fluorosis. However, in order to have anticariogenic potential, the dentifrice should form loosely-bound fluorine (CaF2) on dental enamel. Considering that the formation of CaF2 is a function inversely related to pH, dentifrices with pH 5.5, with 275, 550 and 1,100 ppm F (NaF/silica) were developed in order to assess dose-response effects. A comparison between those… Show more
“…Negri and Cury [2002] also demonstrated that the amount of CaF 2 formed after treatment with an acidic 550-g F/g dentifrice (NaF, pH 5.5) was equivalent to that obtained after use of a commercial 1,100-g F/g dentifrice.…”
This study evaluated the effectiveness of acidic low-fluoride dentifrices compared to conventional neutral dentifrices. Enamel blocks were submitted to pH cycling and treatment with slurries of dentifrices containing 0, 275, 412, 550 and 1,100 µg F/g (pH 4.5 or 7.0), and also a commercial dentifrice (1,100 µg F/g) and a commercial children’s dentifrice (500 µg F/g). Variations in surface microhardness and in the mineral content in enamel after pH cycling were calculated. Enamel blocks treated with acidic dentifrices exhibited less mineral loss compared to neutral dentifrices (ANOVA; p < 0.05). The acidic dentifrices with 412 and 550 µg F/g had the same effectiveness as the neutral 1,100-µg F/g dentifrice and commercial 1,100-µg F/g dentifrice.
“…Negri and Cury [2002] also demonstrated that the amount of CaF 2 formed after treatment with an acidic 550-g F/g dentifrice (NaF, pH 5.5) was equivalent to that obtained after use of a commercial 1,100-g F/g dentifrice.…”
This study evaluated the effectiveness of acidic low-fluoride dentifrices compared to conventional neutral dentifrices. Enamel blocks were submitted to pH cycling and treatment with slurries of dentifrices containing 0, 275, 412, 550 and 1,100 µg F/g (pH 4.5 or 7.0), and also a commercial dentifrice (1,100 µg F/g) and a commercial children’s dentifrice (500 µg F/g). Variations in surface microhardness and in the mineral content in enamel after pH cycling were calculated. Enamel blocks treated with acidic dentifrices exhibited less mineral loss compared to neutral dentifrices (ANOVA; p < 0.05). The acidic dentifrices with 412 and 550 µg F/g had the same effectiveness as the neutral 1,100-µg F/g dentifrice and commercial 1,100-µg F/g dentifrice.
“…The concentrations of 150–1,350 ppm F used in the experiment simulates the dilution 1:3 that occurs in the oral cavity [ 38 ] when toothbrushing with toothpastes of low to high fluoride concentration. Therefore, this model could be used to estimate the anti-caries potential of innovative toothpaste formulations with low fluoride concentration [ 46 ] that could be recommended to control enamel caries in children, and formulations with high fluoride concentrations, that have been suggested to control root caries in elderly people [ 19 , 21 , 22 ]. Furthermore, the model could be used to estimate the anti-caries potential of fluoride on the cervical area in adults and elderly people, where dentine is exposed and enamel and dentine are at the same risk of caries.…”
Due to gingival recession both enamel and root dentine are at risk of developing caries. Both tissues are exposed to a similar environment, however there is not a validated model to evaluate the effect of fluoride on these dental substrates simultaneously. Hence, this study aimed to validate a caries model to evaluate the effect of fluoride to prevent demineralization on enamel and root-dentine. Streptococcus mutans UA159 biofilms were formed on saliva-coated bovine enamel and root dentine slabs (n = 12 per group) mounted in the same well of culture plates. The biofilms were exposed 8×/day to 10% sucrose and treated 2×/day with fluoridated solutions containing 0, 150, 450, or 1,350 ppm F; thus, simulating the use of low to high fluoride concentration toothpastes. The pH values of the culture medium was monitored 2×/day as a biofilm acidogenicity indicator. After 96 h, biofilms were collected for fluoride concentration analysis. The percentage of surface hardness loss (%SHL) was calculated for slabs. The fluoride uptake by the enamel and dentine was also determined. The model showed a dose-response because the biofilm and fluoride uptake increased and %SHL decreased at increasing fluoride concentrations (p < 0.05). Fluoride in the biofilm formed on dentine and fluoride uptake by dentine were higher than those for enamel. With the same fluoride concentration treatment, the percentage of reduction of demineralization was lower for dentine than for enamel. In conclusion, the model was validated in terms of a dose-response effect of fluoride on enamel and root dentine. Furthermore, the findings support the clinical data, suggesting that higher fluoride concentrations are necessary to control caries of root dentine than of enamel.
“…Cabe ressaltar que o método empregado determina a extração de uma camada superficial do esmalte 9 ou seja, em tese, foi determinada a concentração na superfície. Análises na profundidade do esmalte são possíveis somente in vitro 15 . Ainda que não significativa essa diferença na concentração de F -depositado na forma de CaF 2 na superfície do esmalte, podemos pressupor que fatores individuais como pressão exercida durante a escovação, número e velocidade dos movimentos e capacidade de eliminar o remanescente pela expectoração, poderiam interferir na menor concentração de F -depositada quando da realização da EGF, uma vez que interfeririam no tempo de contato da solução com o esmalte dentário.…”
Objetivos: Comparar a concentração de fluoreto depositado sobre o esmalte dentário na forma de fluoreto de cálcio após Aplicação Tópica de Flúor Profissional e Escovação com Gel Fluorado. Método: Vinte escolares de 12 anos de idade foram divididos em dois grupos aleatoriamente. O grupo 1 recebeu Aplicação Tópica de Flúor (ATFP) e o grupo 2 realizou Escovação com Gel Fluorado (EGF). O esmalte dentário foi submetido à biópsia com ácido perclórico 0,1M, tamponado com solução Tissab II. Foi determinada a concentração de fluoreto (F-) pelo método do eletrodo específico. A análise estatística foi realizada através do teste de Mann-Whitney, com intervalo de confiança de 95%. Resultados: As concentrações de fluoreto depositado sobre o esmalte, após ATFP e EGF foram, respectivamente, 11,09+1,42 mgF-/mL e 8,00+0,67 mgF-/mL (p=0,36). Conclusão: Não há diferença entre ATFP e EGF quanto a concentração de fluoreto depositado sobre o esmalte na forma de fluoreto de cálcio.Descritores: Fluoreto de Cálcio; Cárie Dentária; Esmalte Dentário.
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