Efeito do ultrassom e do dexapantenol na organização das fibras colágenas em lesão tegumentar

Guimarães, Gustavo Narvaes; Pires-de-Campos, Maria Silvia Mariani; Leonardi, Gislaine Ricci; Dib-Giusti, Helena H. K.; Polacow, Maria L. O.

doi:10.1590/s1413-35552011000300009

Cited by 11 publications

(3 citation statements)

References 26 publications

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“…Moreover, Dexpanthenol, despite being a drug indicated in the literature as a suitable positive control for studies of skin wounds, it has a better efficacy from D14, since it promotes an increase in collagen synthesis through the activation of fibroblasts, but the rate of synthesis and remodeling of collagen is slow (Guimarães et al, 2011). This helps to explain the fact that only from D14, the animals of G3 showed an evolution of healing similar to the other groups.…”

Section: Discussionmentioning

confidence: 97%

Healing and local anti-inflammatory activity of the aqueous extract of Leonurus sibiricus L. leaves in an animal model

Silva,

Alencar,

Vieira

et al. 2023

RSD

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This study analyzed the healing and local anti-inflammatory activity of compounds from the aqueous extract of leaves of the plant Leonurus sibiricus L. (rubim) by evaluating the resolution of cutaneous wounds made in Wistar rats. The wounds were treated daily with the extract of L. sibiricus 10% (m/v) in sodium alginate 5% (m/v) to obtain a gel that facilitated its application; sodium alginate 5% (m/v) and Dexpanthenol 42 mg/g were used as negative and positive controls, respectively. The wounds were evaluated daily for appearance (crusting, swelling) and reduction during 21 days. The data were statistically analyzed and the results indicated that the extract of L. sibiricus favored a better healing evolution of the wounds when compared to the positive control, besides presenting less inflammatory exudate. Regarding the time of resolution (closure) of the wounds, no significant difference was observed between the animals treated with the extract of L. sibiricus and the negative control, however, the extract of L. sibiricus favored a more homogeneous healing giving the wound a better visual appearance, which was confirmed by microscopic analysis. These results corroborate the common sense knowledge of the population that uses this plant in relation to the indicated therapy.

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Section: Discussionmentioning

confidence: 97%

Healing and local anti-inflammatory activity of the aqueous extract of Leonurus sibiricus L. leaves in an animal model

Silva,

Alencar,

Vieira

et al. 2023

RSD

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“…The literature shows success in the association of topical coverings and LFUS for the treatment of skin lesions. The LFUS provides phonophoresis and, thus, the substances found on the lesion are helped by the waves generated to penetrate the skin layers more easily, accelerating its absorption and its effects on the lesion 8 .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic ultrasound associated with essential oils of copaiba and tea tree for healing skin lesions

Mororó

Brandão

Ponte

et al. 2020

ESTIMA, Braz. J. Enterostomal Ther.

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Objective: to evaluate the effectiveness of low-frequency ultrasound associated with copaiba and tea tree oil gel in healing skin lesions. Method: quasi-experimental study with pre and post-tests in a single group, carried out in a public hospital in Ceará, Brazil, from March to September 2017, with 14 participants who received 10 treatment sessions. Results: there was an average reduction of more than 20 cm² from the 1st to the 5th application. The reduction in the initial size for the 10th session was over 50%. There was statistical significance (p = 0.0043) between the initial evaluation and the 10th therapy evaluation, with an average reduction of 37 cm². There was a reduction in the intensity of pain reported by the participants and 62.5% were free of pain after applying the therapy. Conclusion: the use of the gel with copaiba and tea tree oil points to an alternative coverage associated with biostimulators such as ultrasound. The composition of the gel oil helped in the application and in the reduction of the maceration of the edge of the wounds, as well as the control of the exudate of the lesion.

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“…Physical agents are also employed as adjuncts to facilitate tissue repair including photobiomodulation (PBM), which is also called low‐level laser therapy (LLLT) , ultrasound application and microcurrent application . Nowadays, there is an increasing level of clinical interest in the use of noninvasive therapies that will optimize the repair process, by reduction of engraftment uptake time period as well as objectively enhancing the quality of healing.…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation of a flowable matrix in a human skin ex vivo model demonstrates energy‐based enhancement of engraftment integration and remodeling

Neves

Parizotto

Cominetti

et al. 2018

Journal of Biophotonics

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The use of dermal substitutes to treat skin defects such as ulcers has shown promising results, suggesting a potential role for skin substitutes for treating acute and chronic wounds. One of the main drawbacks with the use of dermal substitutes is the length of time from engraftment to graft take, plus the risk of contamination and failure due to this prolonged integration. Therefore, the use of adjuvant energy-based therapeutic modalities to augment and accelerate the rate of biointegration by dermal substitute engraftments is a desirable outcome. The photobiomodulation (PBM) therapy modulates the repair process, by stimulating cellular proliferation and angiogenesis. Here, we evaluated the effect of PBM on a collagen-glycosaminoglycan flowable wound matrix (FWM) in an ex vivo human skin wound model. PBM resulted in accelerated rate of re-epithelialization and organization of matrix as seen by structural arrangement of collagen fibers, and a subsequent increased expression of alpha-smooth muscle actin (α-SMA) and vascular endothelial growth factor A (VEGF-A) leading to an overall improved healing process. The use of PBM promoted a beneficial effect on the rate of integration and healing of FWM. We therefore propose that the adjuvant use of PBM may have utility in enhancing engraftment and tissue repair and be of value in clinical practice.

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Efeito do ultrassom e do dexapantenol na organização das fibras colágenas em lesão tegumentar

Cited by 11 publications

References 26 publications

Healing and local anti-inflammatory activity of the aqueous extract of Leonurus sibiricus L. leaves in an animal model

Healing and local anti-inflammatory activity of the aqueous extract of Leonurus sibiricus L. leaves in an animal model

Therapeutic ultrasound associated with essential oils of copaiba and tea tree for healing skin lesions

Photobiomodulation of a flowable matrix in a human skin ex vivo model demonstrates energy‐based enhancement of engraftment integration and remodeling

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