Efeito da hiperprolactinemia induzida pela metoclopramida na córnea de camundongas

Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle

“…The animals were randomly divided into 2 groups of 40 animals each: control (Ctr), which were injected daily with drug vehicle (0.2 ml of saline solution), and experimental (HPrl), treated with metoclopramide (6.7 µg/g daily) 6-10. Injections were made by the subcutaneous route at 11 a.m., and the treatments lasted 50 days.…”

“…Metoclopramide is a hyperprolactinemic drug that is used as an antiemetic agent 4,5. In female mice, metoclopramide-induced hyperprolactinemia causes changes in the reproductive system, mainly in ovarian function and the endometrium 6-10. While there is extensive data regarding prolactin regulation and hyperprolactinemic states, the direct effects of metoclopramide on the morphological and functional aspects of pituitary cells remain unknown.…”

The influence of essential fatty acids on the female health

“…Dry eye is a problem that can interfere a lot in people's daily lives, especially affecting activities that require the use of vision, such as reading, driving at night, using the computer, and so on, both professionally and for dilettantism. Some factors seem to influence its appearance, such as aging, female gender, inflammatory and immune processes as well as hypoestrogenism and hyperprolactinemia 17,18 .…”

Expressão gênica da prolactina e seus receptores na hipófise e no útero de camundongo fêmea tratado com metoclopramida

“…Este mensageiro químico, polipeptídico, é sintetizado e secretado principalmente pela hipófise (Verna et al, 2006).…”

“…Assim, foi demonstrada que a utilização de metoclopramida é eficiente para o desenvolvimento de um modelo de hiperprolactinemia experimental (Faglia, 2001;Verna et al, 2006).…”