Efeito da Astrocaryum aculeatum (Tucumã) na toxicidade da Doxorrubicina: modelo experimental in vivo

Carneiro, Alan Bruno Aurélio; Pinto, Eduardo Júnior Serrão; Ribeiro, Ivagner Ferreira; Magalhães, Mayck Rian Gonçalves; Neto, Moacir de Azevedo Bentes Monteiro

doi:10.1590/1982-0194201700036

Cited by 12 publications

(4 citation statements)

References 26 publications

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“…The results obtained are similar to those found in the literature, Carneiro et al (2017) describe, in his study that he used Astrocaryum aculeatum oil, an antigenotoxic activity that varied from 35 to 38% in 24h and 63 to 66% in 48h, observing a slight increase of the percentage of protection of genetic material against the DXR administered in the analysis made 48h after administration of the concentrations, which is due to the protective effect of the administered compounds, which were able to further reduce the effects of DXR even during the peak of genotoxicity in 48h (Okoye et al, 2014).…”

Section: Antigenotoxicitysupporting

confidence: 91%

Cytogenetic evaluation of α, β-amirina obtained in resin of Protium heptaphylum (Aubl.) Marchand in polychromatics erythrocytes of mice swiss.

Rego¹,

Vale²,

Pureza³

et al. 2021

Int J Innov Educ Res

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The Amazon Rainforest has a great variety of medicinal plants, among them we can highlight the “Almecegueira” or “Breu Branco” (Protium heptaphylum) in Portuguese, the producer of a greenish-white resin that hardens when it touches the air, known by its gastroprotective and anti-inflammatory effects. These effects are attributed to a triterpene mixture of α and β amirine, predominant in the resin. The purpose of the study is to obtain a cytogenetic profile to the α, β-amirine mixture obtained in the resin of P. heptaphylum. For this, the micronucleus test was used in peripheral blood and bone marrow; administering solution in Swiss mice with the dosages of 1mg/Kg, 3mg/Kg, and 10mg/Kg, diluted in 5% DMSO, the effects were observed in 24h and 48h after the treatment. For the test in peripheral blood the mice’s caudal vein was punctured, while for the bone marrow test, the femurs of the animals were obtained from which bone marrow samples were taken. It was found that in peripheral blood, the administration of the compounds did not cause genotoxicity in 24h and 48h, in contrast, antigenotoxicity was, for concentrations 1; 3 and 10mg/kg, respectively 10%; 12%; 67% in 24h and 9%; 15%; 73% in 48h. In the bone marrow, no genotoxicity was observed, as for antigenotoxicity was observed that for concentrations 1; 3 e 10mg/kg the percentage of reduction was respectively: 11%, 15%, and 30% in 24h and 13% 16% 33% in 48h. It is concluded that the studied compound can be an alternative for treatments in the future since it presents low toxicity and high antigenotoxic potential.

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Section: Antigenotoxicitysupporting

confidence: 91%

Cytogenetic evaluation of α, β-amirina obtained in resin of Protium heptaphylum (Aubl.) Marchand in polychromatics erythrocytes of mice swiss.

Rego¹,

Vale²,

Pureza³

et al. 2021

Int J Innov Educ Res

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“…Doxorubicin, an important chemotherapeutic with cytotoxic activity on several types of cancer, was used as a positive control to estimate the viability of tumor cells [30]. This drug, as well as the compounds evaluated in this study, is a quinone and has a structure capable of releasing free radicals that cause cellular stress [31].…”

Section: Lawsone Derivatives Reduce the Viability Of Tumor Cell Linesmentioning

confidence: 99%

Anti-proliferative and pro-apoptotic activity of glycosidic derivatives of lawsone in melanoma cancer cell

et al. 2021

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Background Melanoma is a malignant cancer that affects melanocytes and is considered the most aggressive skin-type cancer. The prevalence for melanoma cancer for the last five year is about one million cases. The impact caused of this and other types of cancer, revel the importance of research into potential active compounds. The natural products are an important source of compounds with biological activity and research with natural products may enable the discovery of compounds with potential activity in tumor cells. Methods The Sulforhodamine B was used to determine cell density after treatment with lawsone derivatives. Apoptosis and necrosis were analyzed by flow cytometer. Morphological changes were observed by fluorescence using the Phalloidin/FITC and DAPI stains. The clonogenic and wound healing assays were used to analyze reduction of colonies formation and migratory capacity of melanoma cells, respectability. Results In pharmacological screening, seven compounds derived from lawsone were considered to have high cytotoxic activity (GI > 75%). Three compounds were selected to assess the inhibitory concentration for 50% of cells (IC50), and the compound 9, that has IC50 5.3 μM in melanoma cells, was selected for further analyses in this cell line. The clonogenic assay showed that the compound is capable of reducing the formation of melanoma colonies at 10.6 μM concentration. The compound induced apoptotic morphological changes in melanoma cells and increased by 50% the cells dying from apoptosis. Also, this compound reduced the migratory capacity of melanoma cells. Conclusions The results of this study showed that the evaluated lawsone derivatives have potential activity on tumor cells. The compound 9 is capable of inducing cell death by apoptosis in melanoma cells (B16F10).

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“…Carneiro et al [ 65 ] evaluated the genotoxicity/antigenotoxicity activity of tucumã oil using the micronucleus test in micronucleated polychromatic erythrocytes. The study was conducted with healthy male Swiss mice (6–7 weeks of age).…”

Section: Biological Effects Of Fruits Of Amazonian Palm Treesmentioning

confidence: 99%

Amazonian palm tree fruits: From nutritional value to diversity of new food products

Amorim,

Godoy

et al. 2024

Heliyon

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Efeito da Astrocaryum aculeatum (Tucumã) na toxicidade da Doxorrubicina: modelo experimental in vivo

Cited by 12 publications

References 26 publications

Cytogenetic evaluation of α, β-amirina obtained in resin of Protium heptaphylum (Aubl.) Marchand in polychromatics erythrocytes of mice swiss.

Cytogenetic evaluation of α, β-amirina obtained in resin of Protium heptaphylum (Aubl.) Marchand in polychromatics erythrocytes of mice swiss.

Anti-proliferative and pro-apoptotic activity of glycosidic derivatives of lawsone in melanoma cancer cell

Amazonian palm tree fruits: From nutritional value to diversity of new food products

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