“…1 Its origin is multifactorial, and it has been associated with three major factors: biological, behavioral, and psychological, the latter contemplates the effects of stress on the central nervous system (CNS), the cardiovascular system, negative emotions (anger, anxiety, or depression), and individual variables. [2][3][4] High blood pressure has been associated with psychological factors such as stress, anxiety, depression, and personality, 2,4 these findings indicate that stress and emotional reactions represent physiological correlates in which the CNS regulates peripheral vascular activity, which affects glandular secretions, organs, muscles, blood and different processes, which can have a triggering or aggravating role in certain disorders such as arterial hypertension. The link between stress and cardiovascular disease is given by several psychobiological mechanisms and the acute and chronic activation of the sympathetic nervous system that can contribute to the development of hypertension or worsening of blood pressure (BP) levels in blood; 5 in addition, in situations of prolonged stress mood worsening and increased cortisol have been reported.…”