Efectos de los ácidos grasos omega 3 y otros suplementos alimenticios en procesos patológicos relacionados con la tercera edad

Rueda, Félix; Domingo, Joan Carles; Mach, Núria

doi:10.1016/s2173-1292(11)70004-7

Cited by 4 publications

(5 citation statements)

References 87 publications

(65 reference statements)

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“…These results are consistent with those of other authors and provide evidence for the protective role of n-3 PUFA through reducing the levels of these LCcer. 27,28 Studies using knockout mice for C24:0 ceramide provide further evidence for the protective role of VLCcer. Raichur et al found that the knockout mice were indistinguishable from wild-type mice in groups fed with normal chow.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of fish oil on pre-diabetes: a lipidomic analysis of liver ceramides in rats

et al. 2016

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A high intake of fat and sucrose can dramatically increase bioactive lipids such as ceramides in tissues. Ceramides regulate several steps in the insulin signal pathway. The effects of n-3 PUFA on insulin resistance are inconsistent, especially in liver. We investigated the effect of n-3 PUFA (EPA/DHA 1 : 1) from fish oil on hepatic ceramides in a pre-diabetic animal model. Three groups of rats were fed standard feed, high fat high sucrose feed (HFHS) or HFHS enriched with n-3 PUFA. We investigated by lipidomic analysis how supplementation of a HFHS diet with n-3 PUFA modifies the hepatic ceramide profile triggered by a HFHS diet. Our results show that n-3 PUFA modified the ceramide profile of the liver and reduced their total content in pre-diabetic rats. Significant linear correlations were observed between ceramides and biochemical insulin parameters. Long chain ceramide 18:1/18:0 showed a positive correlation with the HOMA index. Very long chain ceramide 18:1/24:0 showed a negative correlation with insulin and the HOMA index. Finally, very long chain ceramide 18:1/20:0 correlated negatively with glucose levels, plasmatic insulin levels and the HOMA index. In conclusion, the modulation of the ceramide profile in pre-diabetic rats may explain the protective action of n-3 PUFA against liver insulin resistance (IR) caused by an HFHS diet. We confirm the protective role of very long chain ceramide 18:1/24:0 and the harmful role of long chain ceramide 18:1/18:0 in the pre-diabetic state and propose ceramide 18:1/20:0 as a biomarker of early liver IR in rats.

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Section: Discussionmentioning

confidence: 99%

Protective effects of fish oil on pre-diabetes: a lipidomic analysis of liver ceramides in rats

et al. 2016

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“…Another important contribution of this work is the identification of linoleic and αlinoleic acids, also known as omega-6 and omega-3 fatty acids. These essential fatty acids are metabolized to yield arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid, which are involved in the regulation of blood pressure and inflammatory response (Rueda, Domingo, & Mach, 2011).…”

Section: Application Of Vanilla Compounds Identifiedmentioning

confidence: 99%

Volatile compounds and fatty acids in oleoresins fromVanilla PlanifoliaAndrews obtained by extraction with supercritical carbon dioxide

Hernández-Fernández

Rojas-Ávila

Vázquez‐Landaverde

et al. 2019

CyTA - Journal of Food

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Vanilla is currently sold as an ethyl alcoholic extract, typically at a concentration of 35% (v/v). Alcoholic extracts have some disadvantages, such as high concentrations of organic residues, long extraction times and the requirement of large volumes when used as a flavoring. In contrast, supercritical fluid extraction (SFE) allows isolation of high-purity oleoresins without co-extraction of undesired organic residues, thereby preserving the desired volatile compounds in vanilla. In this study, we identified and quantified volatile compounds and fatty acids in four oleoresins and two ethanolic extracts of cured Vanilla planifolia Andrews beans following 10 or 20 sun-drying and sweating cycles (SS). SFE was carried out at a pressure of 20 MPa at 40°C, 50°C, or 60°C, and the resulting vanilla oleoresins were analyzed with GC-MS and GC-FID. The major compounds identified in the extracts were o-guaiacol, p-creosol, p-vinylguaiacol, p-hydroxybenzaldehyde, vanillic acid and vanillin.

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“…El grado del estado de nutrición fue analizado como respuesta categórica con 79 valores de [1] pacientes con un estado nutricional adecuado: puntuación total >23,5 80 puntos, [2] pacientes con riesgo de malnutrición con puntuaciones ≥17 a 23,5, y [3] 81 pacientes con malnutrición proteico calórica o <17 puntos. 82…”

Section: Análisis Estadístico 78unclassified

“…Los ancianos representan un segmento creciente de la población mundial que 26 está requiriendo y utilizando una porción cada vez mayor de recursos de los sistemas de 27 salud (1). Varios estudios demuestran que una parte importante de esta población 28 presenta malnutrición o nutrición inadecuada que puede agravar la prevalencia de 29 enfermedades crónicas o invalidantes que determinan una creciente atención socio-30 sanitaria a domicilio (2).…”

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Riesgo de malnutrición en la población mayor de 75 años

Valls¹,

Mach²

2012

Medicina Clínica

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Efectos de los ácidos grasos omega 3 y otros suplementos alimenticios en procesos patológicos relacionados con la tercera edad

Cited by 4 publications

References 87 publications

Protective effects of fish oil on pre-diabetes: a lipidomic analysis of liver ceramides in rats

Protective effects of fish oil on pre-diabetes: a lipidomic analysis of liver ceramides in rats

Volatile compounds and fatty acids in oleoresins fromVanilla PlanifoliaAndrews obtained by extraction with supercritical carbon dioxide

Riesgo de malnutrición en la población mayor de 75 años

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