Efectos benéficos de los compuestos antioxidantes de la granada (Punica granatum L.) en patologías asociadas con el estrés oxidante

Abstract

Pomegranate (Punica granatum L.) is a fruit
 rich in bioactive compounds with various biological
 properties that help maintain good health. In particular,
 the polyphenolic compounds punicalagin, ellagic acid,
 urolithins and gallic acid are among the main molecules
 with antioxidant potential identified in this fruit;
 that is, these compounds have the ability to prevent
 cellular alterations caused by oxidative stress and/or
 induce the body’s own antioxidant response to protect
 cells. As a result, numerous scientific studies have
 emerged in the last decade, focused on recognizing
 the pharmacological properties of these molecules, to
 prevent the development and progression of diseases
 in which oxidative stress plays a fundamental role.
 The objectives of this review are: 1) to point out the
 importance of antioxidants obtained from the diet
 and in particular those obtained from pomegranate,
 2) to highlight the beneficial effects of ellagitannins,
 ellagic acid, urolithins and gallic acid against various
 pathologies, and 3) recognize that despite their potential
 as therapeutic agents, further research in humans is
 required to promote their use in the clinic.