Efecto del estrés sobre la inhibición por prepulso: revisión sistemática

Pujante-Gil, Sergio; Manzanedo, Carmen; Arenas, M. Carmen

doi:10.33588/rn.7204.2020441

Cited by 2 publications

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“…From an applied perspective, PPI represents a measure of the integrity of the central nervous system, being a neurobiological operational measure that could reflect the functioning of the dopaminergic system [ 49 , 52 ]. Considering the transdiagnostic nature of the deficit, and that it could be considered as an index of susceptibility or psychopathological risk, in the future, when the representativeness of the studies is greater and the studies include samples of patients at different stages of the disorders, it could be employed as a marker of state-trait disease.…”

Section: Discussionmentioning

confidence: 99%

“…PPI has been suggested as a translational research tool [ 47 , 48 ], since its deficit has been verified in different neuropsychiatric disorders with common neurobiological correlates [ 49 , 50 ], and by the presence of affective components such as anxiety and stress [ 51 , 52 ]. Specifically, the group where the most potent evidence of a PPI deficit is found is in schizophrenia spectrum disorders, where this deficit has been proposed as a biomarker [ 53 , 54 ] and an endophenotype [ 55 – 57 ] of psychosis.…”

Section: Introductionmentioning

confidence: 99%

“…According to the fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (American Psychiatric Association [ 67 ]), the main trauma- and stressor-related disorders are Post-Traumatic Stress Disorder (PTSD) and acute stress disorder, while anxiety disorders are mainly social anxiety disorder, panic disorder, and generalized anxiety disorder. With respect to PPI deficit, some contradictory results have been reported for panic disorder, PTSD, and social anxiety disorder [ 52 , 68 ].…”

Section: Introductionmentioning

confidence: 99%

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Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: a systematic review

Santos-Carrasco,

De la Casa

2023

BMC Psychol

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Background Psychopathological research is moving from a specific approach towards transdiagnosis through the analysis of processes that appear transversally to multiple pathologies. A phenomenon disrupted in several disorders is prepulse inhibition (PPI) of the startle response, in which startle to an intense sensory stimulus, or pulse, is reduced if a weak stimulus, or prepulse, is previously presented. Objective and methods The present systematic review analyzed the role of PPI deficit as a possible transdiagnostic process for four main groups of neuropsychiatric disorders: (1) trauma-, stress-, and anxiety-related disorders (2) mood-related disorders, (3) neurocognitive disorders, and (4) other disorders such as obsessive-compulsive, tic-related, and substance use disorders. We used Web of Science, PubMed and PsycInfo databases to search for experimental case-control articles that were analyzed both qualitatively and based on their potential risk of bias. A total of 64 studies were included in this systematic review. Protocol was submitted prospectively to PROSPERO 04/30/2022 (CRD42022322031). Results and conclusion The results showed a general PPI deficit in the diagnostic groups mentioned, with associated deficits in the dopaminergic neurotransmission system, several areas implied such as the medial prefrontal cortex or the amygdala, and related variables such as cognitive deficits and anxiety symptoms. It can be concluded that the PPI deficit appears across most of the neuropsychiatric disorders examined, and it could be considered as a relevant measure in translational research for the early detection of such disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: a systematic review

Santos-Carrasco,

De la Casa

2023

BMC Psychol

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Prepulse Inhibition Deficit as a Transdiagnostic Process in Neuropsychiatric Disorders: A Systematic Review

Santos‐Carrasco

Casa

2023

Preprint

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Psychopathological research is moving from a specific approach towards transdiagnosis through the analysis of processes that appear transversally to multiple pathologies. A phenomenon disrupted in several disorders is prepulse inhibition (PPI) of the startle response, in which startle to an intense sensory stimulus, or pulse, is reduced if a weak stimulus, or prepulse, is previously presented. The present systematic review analyzed the role of PPI deficit as a possible transdiagnostic process for three main groups of neuropsychiatric disorders: 1) trauma-, stress-, and anxiety-related disorders 2) mood-related disorders, and 3) neurocognitive disorders. We used Web of Science, Pubmed and PsycInfo databases to search for experimental case-control articles that were analyzed both bibliometrically and based on their potential risk of bias. A total of 41 studies were included in this systematic review. The results showed a general PPI deficit in the three diagnostic groups mentioned, with associated deficits in the dopaminergic neurotransmission system, several areas implied such as the medial prefrontal cortex or the amygdala, and related variables such as cognitive deficits and anxiety symptoms. It can be concluded that the PPI deficit is a transdiagnostic process across most of the neuropsychiatric disorders examined, and it is a relevant measure in translational research for the early detection and intervention of such disorders. Protocol submitted prospectively to PROSPERO 04/30/2022 (CRD42022322031).

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Efecto del estrés sobre la inhibición por prepulso: revisión sistemática

Cited by 2 publications

References 0 publications

Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: a systematic review

Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: a systematic review

Prepulse Inhibition Deficit as a Transdiagnostic Process in Neuropsychiatric Disorders: A Systematic Review

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