Efecto de metformina sobre la expresión del factor de necrosis tumoral-&amp;#945;, los receptores Toll-like 2/4 y la PCR ultra sensible en sujetos obesos con diabetes tipo 2

Andrews, Mónica; Soto, Néstor; Arredondo, Miguel

doi:10.4067/s0034-98872012001100001

Cited by 39 publications

(17 citation statements)

References 23 publications

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“…Intriguingly, our study failed to show elevated serum TNFα, IL-6, IFNβ, IL-8, IL-10, IL-12 and IFNγ levels in T2DM subjects despite perturbations in cytokine/TLR mRNAs levels being evident in the monocytes and neutrophils taken from T2DM patients. In terms of TLR expression, studies have shown that metformin 33 , statins, PPAR-γ agonists 34 and angiotensin receptor blockers 35 lower the expression of TLR2 and TLR4 in T2DM patients. Further, previous studies have shown that insulin infusion significantly suppressed TLRs 1, 2, 4, 7, and 9 mRNA expressions in mononuclear cells obtained from T2DM individuals 18 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications

Gupta

Maratha

Siednienko

et al. 2017

Sci Rep

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The pathogenesis and complications of type 2 diabetes (T2DM) are closely linked with defective glucose metabolism, obesity, cardiovascular disease and an inability to mount an effective immune response to certain pathogenic organisms. Perturbations in key innate immune receptors known as Toll-like receptors (TLRs) and inflammatory mediators such as IL-6, TNFα and IL-1β have been linked with T2DM. Herein, we sought to establish whether patients with T2DM and underlying complications exhibit perturbations in cytokine and TLR expression. Serum cytokine and mRNA levels of cytokines/TLRs in monocytes (M) and neutrophils (N) were measured in a cohort of 112 diabetic patients: good glycaemic control without complications (GC), good glycaemic control with complications (GCC), poor glycaemic control without complications (PC) and poor glycaemic control with complications (PCC) and compared them with 34 non-diabetic volunteers (NGT). Serum cytokine levels were normal in all study participants. In the GC group, cytokine and TLR gene expression were enhanced compared to NGT. In contrast, suppressed cytokine and TLR gene expression were evident in PC, GCC & PCC groups when compared to the GC. In conclusion, whereas serum pro-inflammatory cytokine levels are unaltered in T2DM patients, differences in inflammatory gene profiles exist among the T2DM patient groups.

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Section: Discussionmentioning

confidence: 99%

Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications

Gupta

Maratha

Siednienko

et al. 2017

Sci Rep

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“…Another secondary finding is that metformin is associated with an increased RA risk. This finding was unexpected because previous studies have found metformin to be associated with decreased levels of inflammatory markers 47 48 . However, hyperhomocysteinemia, which is a potential side effect of metformin 49 , has been found to be associated with elevated levels of immune activation markers in RA patients 50 .…”

Section: Discussionmentioning

confidence: 71%

Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice

Chen

Chao

et al. 2015

Sci Rep

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Acarbose has been found to decrease some inflammatory parameters in diabetic patients. This study aimed to examine the influence of acarbose on rheumatoid arthritis (RA) risk in diabetes mellitus (DM) patients and on the incidence and severity of collagen-induced arthritis (CIA) in mice. In a nationwide, matched case–control study, we identified 723 incident RA cases and selected 7,230 age-, sex- and RA diagnosis date–matched controls from all newly treated DM patients. We found that use of acarbose at > 16,950 mg per year was associated with a lower RA risk (odds ratio 0.60; 95% CI, 0.41–0.89). In the CIA mouse study, acarbose was orally administered from days -7 to 38 relative to type II collagen (CII) immunization. The results revealed that acarbose at the dose of 500 mg/kg/day attenuated the incidence and severity of arthritis and the expression of proinflammatory cytokines, including TNF-α, IL-6 and IL-17 in the paw tissues. Acarbose further decreased the productions of anti-CII-IgG, IL-17 and IFN-γ by collagen-reactive lymph node cells. This work suggests that the use of acarbose decreased RA risk in DM patients and the incidence of CIA in mice. Acarbose also attenuated the severity of CIA via anti-inflammatory and immunomodulatory effects.

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“…Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) will be the house-keeping gene. The primers to be used in the study are listed in Table 1, based on literature research [18–20]. …”

Section: Methodsmentioning

confidence: 99%

Research proposal: inflammation and oxidative stress in coronary artery bypass surgery graft: comparison between diabetic and non-diabetic patients

et al. 2018

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BackgroundDiabetes mellitus patients (DM) have more severe progression of atherosclerotic disease than non-diabetic (NDM) individuals. In situ inflammation and oxidative stress are key points in the pathophysiology of atherosclerosis, a concept largely based on animal model research. There are few studies comparing inflammation and oxidative stress parameters in medium-sized arteries between DM and NDM patients. A fragment of the internal mammary artery used in coronary artery bypass grafting (CABG) will be employed for this purposeObjectiveTo assess the expression of inflammatory markers tumor necrosis factor-α, transforming growth factor-β1, nuclear factor kappa B, the enzymes superoxide dismutase, and catalase in the vascular wall of the arterial graft used in CABG, comparing DM and NDM patientsResultsThe present study will add information to the vascular degenerative processes occurring in diabetic patients.

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Efecto de metformina sobre la expresión del factor de necrosis tumoral-α, los receptores Toll-like 2/4 y la PCR ultra sensible en sujetos obesos con diabetes tipo 2

Cited by 39 publications

References 23 publications

Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications

Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications

Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice

Research proposal: inflammation and oxidative stress in coronary artery bypass surgery graft: comparison between diabetic and non-diabetic patients

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