Efecto de los niveles séricos de vitamina D en el pronóstico del melanoma cutáneo

Moro, Ruggero; Sánchez-Silva, Ana; Aguerralde-Martin, Maider; González‐Cuevas, Rubén; Peruilh-Bagolini, Leonardo; Traves, Víctor; Manrique‐Silva, Esperanza; Requena, Celia; Nagore, Eduardo

doi:10.1016/j.ad.2021.11.001

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…Regarding melanoma prognosis, lower serum vitamin D 3 levels are significantly related to worse prognostic traits, namely Breslow thickness, along with poorer melanoma survival, even adjusting for inflammatory biomarkers [52]. Several studies have shown similar associations: one studied patients with variations in the gene coding for vitamin D-binding protein predisposing to lower serum vitamin D levels, with poorer melanomaspecific survival [53], and another confirming a significant association between vitamin D levels at diagnosis and location, tumor mitotic rate, and ulceration [54], and a more recent one observing vitamin D levels < 9.25 ng/mL as independent prognostic factor for overall survival in melanoma patients, linked to histologic ulceration [55]. Likewise, low vitamin D levels are related to increased susceptibility to melanoma, along with reduced melanoma survival [6].…”

Section: Vitamin D and Cutaneous Melanomamentioning

confidence: 73%

Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review

Martín-Gorgojo¹,

Gilaberte

Nagore

2021

Nutrients

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Background: The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. There are still multiple controversies. This review aims to give practical recommendations regarding vitamin D among people at risk or with a personal history of skin cancer. Methods: Narrative review including human research articles published between 2011 and 2021, elaborated bearing in mind an epidemiological, patient-centered approach. Results: Ultraviolet (UV) exposure (neither artificial nor natural) is not the ideal source to synthesize vitamin D. There is conflicting epidemiological evidence regarding vitamin D, non-melanoma skin cancer (NMSC), and cutaneous melanoma (CMM), confounded by the effect of sun exposure and other factors. Conclusions: Current evidence is controversial, and there are no widely applicable strategies. We propose three practical recommendations. Firstly, sun protection recommendations should be kept among people at risk or with a personal history of skin cancer. Secondly, vitamin D should preferably be sourced through diet. In patients with melanoma or at risk of cutaneous cancer, serum vitamin D checks are warranted to detect and avoid its insufficiency.

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