Abstract:Effect of angiotensin II synthesis inhibition on alcohol consumption Background: Central renin-angiotensin system modulates alcohol intake and inhibition of angiotensin converting enzyme reduces ethanol consumption in rats, and may be potentially useful in the treatment of alcoholism. Aim: To study the effect of captopril on alcohol intake, both in humans and animals. Material and methods: In a double-blind, placebo-controlled clinical study, 15 alcoholics who met DSM-IV criteria were randomized to receive cap… Show more
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