Efecto de Diferentes Aditivos sobre el Comportamiento Reológico de Masas de Harina de Plátano Dominico Hartón (Musa paradisiaca L.)

Montoya, Jairo; Giraldo, Germán Urrego; Sánchez, Leidy T.

doi:10.4067/s0718-07642019000400003

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References 21 publications

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“…Among the heterocyclic compounds, 4-Thaiazolidinone endowing heteroatoms such as nitrogen, Oxygen and sulfur are ve membered heterocyclic compounds which are known to exhibit a diverse range of pharmacological activities [3][4][5][6]. Drugs based on thiazolidinones core such as Pioglitazone, Troglitazone, Rosiglitazone Rivoglitazone, and Balaglitazone as shown in Chart1., have already been approved for the treatment of type diabetic and in ammatory conditions [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Computational studies, DNA-binding and cytotoxicity of 4-Thiazolidonone-cyclopropyl hybrid

Mushtaque¹,

Avecilla²,

Jahan³

et al. 2021

Preprint

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A derivative of 4-Thiazolidinone derivative endowing cyclopropyl ring substituted at 3-nitrogen positioned was synthesized that was further evaluated against cancerous cell lines MCF-7. The structure of synthesized compound (6) was well characterized by different spectral techniques such as FT-IR, UV-Visible, 1H-NMR, 13C-NMR and mass spectrophotometer. X-ray single crystal structure and Computational study (DFT) study revealed that compound (6) adopted (2Z, 5Z)-configuration. Preliminary In vitro study suggested that compound (6) displayed moderate activity bearing IC50(161.0 μM). The DNA binding studies (Ct-DNA) with compound (6) was performed. The study suggested that bound with DNA exhibiting binding constant Kb = 3.3 x 104 LMol-1). Furthermore, the binding study was complemented by Molecular docking possessingDNA binding studies (Ct-DNA) were performed. Final compound (6) exhibited moderate cytotoxicity effect (IC50 = 161.0 μM) and DNA binding ability (Kb = 3.3 x 104 LMol-1). The experimental findings were completed by molecular docking study.

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Section: Introductionmentioning

confidence: 99%