Eetremely high level of alkaline phosphatase in adult patients as a maintestation of bacteremia

Peng, Yen‐Chun; Yang, Dar-Yu; Hu, We-Hsiung; Hung, Dong-Zong; Chang, Cheng-Chen; Tung, C. J.

doi:10.1016/s0016-5085(08)82869-7

Cited by 5 publications

(6 citation statements)

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“…Similarly, our patient presented with clinical features suggestive of cholestatic jaundice but fortunately the diagnosis of mycotic aneurysm was not delayed due to the imaging investigation performed. The deranged liver enzymes in our patient was most likely due to underlying bacteraemia as demonstrated in previous studies (Tung et al, 2005;Kanai et al, 2008). Interestingly, between 40 to 63.6% of the patients did experienced episode of gastroenteritis before the onset of mycotic aneurysm (Fernández Guerrero et al, 2004).…”

Section: Discussionsupporting

confidence: 78%

Salmonella enteritidis abdominal aorta mycotic aneurysm presented with acute cholestatic jaundice: A case report and literature review

A.A.¹

2023

Trop Biomed

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Mycotic aneurysm is one of the extra-intestinal manifestations of Salmonella Enteritidis infection. The diagnosis of this condition is challenging owed to its variation in clinical presentations. We presented a case of a 54-year-old man with underlying diabetes mellitus and chronic smokers presented with acute right flank pain and fever associated with mild jaundice. The initial laboratory investigations suggested features of obstructive jaundice and urinary tract infection. The contrast enhancing computed tomography of the abdomen revealed the presence of saccular mycotic aneurysm located at the infrarenal abdominal aorta. The blood culture grew Salmonella Enteritidis which was susceptible to ceftriaxone, trimethoprim-sulfamethoxazole, ciprofloxacin, ampicillin, and amoxicillin-clavulanic acid. Intravenous ceftriaxone was initiated, and he underwent open surgery and artery repair at day 8 of admission. He responded well to the treatment given and subsequently discharged home after completed three weeks of intravenous ceftriaxone.

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Section: Discussionsupporting

confidence: 78%

Salmonella enteritidis abdominal aorta mycotic aneurysm presented with acute cholestatic jaundice: A case report and literature review

A.A.¹

2023

Trop Biomed

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“…Hyperbilirubinemia and elevated alkaline phosphatase (AP) are associated with systemic infectious diseases and septic state [7][8][9][10][11]. Hyperbilirubinemia during infectious diseases seems to be the consequence of intrahepatic cholestasis induced by inflammatory cytokines [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Inflammation Markers in Predicting Perforation in Acute Sigmoid Diverticulitis

Käser¹,

Fankhauser²,

Glauser³

et al. 2010

World j. surg.

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“…A small observational study further suggested the close relationship between an extremely high ALP level and bacteremia [37]. In that study, the authors speculated that the observed extremely high ALP level was the result of bacteremia-related hepatic dysfunction.…”

Section: Discussionmentioning

confidence: 95%

Development and Validation of a Clinical Prediction Rule for Bacteremia among Maintenance Hemodialysis Patients in Outpatient Settings

Sasaki

Hasegawa

Kawarazaki³

et al. 2017

PLoS ONE

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BackgroundTo our knowledge, no reliable clinical prediction rule (CPR) for identifying bacteremia in hemodialysis (HD) patients has been established. The aim of this study was to develop a CPR for bacteremia in maintenance HD patients visiting the outpatient department.MethodsThis multicenter cohort study involved consecutive maintenance HD patients who visited the outpatient clinic or emergency room of seven Japanese institutions between August 2011 and July 2013. The outcome measure was bacteremia diagnosed based on the results of blood cultures. The candidate predictors for bacteremia were extracted through a literature review. A CPR for bacteremia was developed using a coefficient-based multivariable logistic regression scoring method, and calibration was performed. The test performance was then assessed for the CPR.ResultsOf 507 patients eligible for the study, we analyzed the 293 with a complete dataset for candidate predictors. Of these 293 patients, 48 (16.4%) were diagnosed with bacteremia. At the conclusion of the deviation process, body temperature ≥ 38.3°C, heart rate ≥ 125 /min, C-reactive protein ≥ 10 mg/dL, alkaline phosphatase >360 IU/L, and no prior antibiotics use within the past week were retained and scored. The CPR had a good fit for the model on calibration. The AUC of the CPR was 0.76, and for score CPR ≥ 2, the sensitivity and specificity were 89.6% and 51.4%, respectively.ConclusionsWe established a simple CPR for bacteremia in maintenance HD patients using routinely obtained clinical information in an outpatient setting. This model may facilitate more appropriate clinical decision making.

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Eetremely high level of alkaline phosphatase in adult patients as a maintestation of bacteremia

Cited by 5 publications

References 0 publications

Salmonella enteritidis abdominal aorta mycotic aneurysm presented with acute cholestatic jaundice: A case report and literature review

Salmonella enteritidis abdominal aorta mycotic aneurysm presented with acute cholestatic jaundice: A case report and literature review

Diagnostic Value of Inflammation Markers in Predicting Perforation in Acute Sigmoid Diverticulitis

Development and Validation of a Clinical Prediction Rule for Bacteremia among Maintenance Hemodialysis Patients in Outpatient Settings

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