EEMCO Guidance for the Assessment of Transepidermal Water Loss in Cosmetic Sciences

Rogiers, Vera

doi:10.1159/000056341

Cited by 462 publications

(486 citation statements)

References 62 publications

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“…12) Recently, it has been reported that skin barrier function in hairless mice is improved by intake of extracts of food materials containing glucosylceramide; the purity was > 6%. 13) It has also been reported that oral intake of glucosylceramide reduced transepidermal water loss (TEWL) 14) in normal adult 12) or in AD patients. 15,16) A. konjac, a rich source of glucocylceramide, has been eaten as food for a long time in Japan.…”

Section: Introductionmentioning

confidence: 99%

Oral Intake of Glucosylceramide Improves Relatively Higher Level of Transepidermal Water Loss in Mice and Healthy Human Subjects

Uchiyama

Nakano

Ueda

et al. 2008

JOURNAL OF HEALTH SCIENCE

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We examined the effect of oral intake of pure glucosylceramide derived from konjac extract on skin barrier function evaluated by transepidermal water loss (TEWL) in hairless mice with sodium dodecyl sulfate (SDS)-induced skin roughness. The difference of TEWL between SDS-treated site and untreated sites in the pure glucosylceramide-fed group was significantly lower than that in control group on day 14 of ingestion. We investigated interleukin-1α (IL-1α) production in the hairless mouse skin, and it was significantly lower in the glucosylceramide-fed group than that of control animals. This reduced IL-1α production should contribute to improvement of skin barrier function. To investigate the effect of oral intake of glucosylceramide in human, we conducted a randomized double-blind placebo-controlled study including 100 healthy subjects whose TEWL in cheek was relatively high. As a result, cheek TEWL was significantly lower in the test product group as compared with the control group in weeks 8 and 12 of ingestion (p = 0.023 and p = 0.002 respectively).

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Section: Introductionmentioning

confidence: 99%

Oral Intake of Glucosylceramide Improves Relatively Higher Level of Transepidermal Water Loss in Mice and Healthy Human Subjects

Uchiyama

Nakano

Ueda

et al. 2008

JOURNAL OF HEALTH SCIENCE

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“…Subsequently, the SC capacitance was measured using a Corneometer®CM (Courage & Khazaka), according to previously reported specifications. 14,15 Measurements were performed on subjects' skin of the inner thigh, buttock, and inner upper arm. Crying infants were not measured until they became quiet or fell asleep.…”

Section: Methodsmentioning

confidence: 99%

Differences in the stratum corneum of Indonesian infants and adults

Fujimura¹,

Shima²,

Miyauchi³

et al. 2017

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Background Although understanding the stratum corneum (SC) of infant skin is important to avoid skin diseases such as atopic dermatitis, there has been no such investigation in Indonesian infants to date. Objective To obtain a basic knowledge of SC characteristics in Indonesian infants in order to develop methods for infant-specific skin care and to prevent dermatitis and infection. Methods Seventy-two healthy, full term infants aged 1 to 24 months who were native Indonesians residing in Jakarta were enrolled in this study. Some of the mothers were also enrolled in the study as adults (n=30). Transepidermal water loss (TEWL) and hydration of the SC (capacitance) on the thigh, buttock, and upper arm were measured after sufficient acclimation in an air-conditioned room, in both infants and mothers. Results The SC hydration was significantly higher in infants than adults at all sites measured, including the buttocks, which is a diaper area. Infant TEWL values were also significantly higher than in adults at all sites. Hydration of the SC and TEWL values showed no significant correlation with age of infant for any site. The SC hydration and TEWL values of Indonesian infants did not decrease to adult values within 24 months, which indicates that the SC characteristics in infants continue to develop after 24 months of age. Conclusion Indonesian infants aged 0-24 months have significantly higher SC hydration and TEWL values than Indonesian mothers. However, infant age has no correlation to SC hydration or to TEWL values.

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“…The amount of water evaporated through the skin can be measured and used for characterizing the epidermal barrier function. If the dermal barrier is damaged, more water can evaporate on the skin than in the case of an intact barrier [12][13][14][15]. TEWL measurements are performed using a small, highly sensitive electrode system, through which the water vapour separated through the skin is led.…”

Section: Biophotonicsmentioning

confidence: 99%

“…The measurements had always been taken on the same skin site for a period of 20 s and stopped when the standard deviation was less than 0.15 g m À2 h À1 . The measurements were carried out in accordance with the published guidelines [13,15].…”

Section: Determination Of Transepidermal Water Loss Values (Tewl)mentioning

confidence: 99%

Comparison between TEWL and laser scanning microscopy measurements for the in vivo characterization of the human epidermal barrier

Vergou

Schanzer

Richter

et al. 2011

Journal of Biophotonics

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The analysis of the skin barrier properties is important in various fields of medical treatment and cosmetology. The development and improvement of topically applied substances require an objective analysis of the skin barrier characteristics. Transepidermal water loss (TEWL) measurement is the standard method to characterize epidermal barrier function. The most important disadvantage of this method though, is that it can be affected by different exogenous and endogenous factors, e.g. water content of the applied formulation and room temperature. In the present study, TEWL measurements are compared to laser scanning microscopic (LSM) measurements, concerning the use of these two methods for the non‐invasive in vivo characterization of the epidermal barrier function. The investigations were performed prior and subsequent to treatment of dry skin with a gel mixture, developed for skin treatment after radiotherapy for cancer. The present results indicate that in vivo laser scanning microscopy is an appropriate method for the characterization of the skin barrier structure without interference by external factors. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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EEMCO Guidance for the Assessment of Transepidermal Water Loss in Cosmetic Sciences

Cited by 462 publications

References 62 publications

Oral Intake of Glucosylceramide Improves Relatively Higher Level of Transepidermal Water Loss in Mice and Healthy Human Subjects

Oral Intake of Glucosylceramide Improves Relatively Higher Level of Transepidermal Water Loss in Mice and Healthy Human Subjects

Differences in the stratum corneum of Indonesian infants and adults

Comparison between TEWL and laser scanning microscopy measurements for the in vivo characterization of the human epidermal barrier

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