EEG-Veränderungen bei diabetischen Kindern

Gilhaus, K. H.; Daweke, H.; Lülsdorf, H. G.; Sachsse, R; Sachsse, B

doi:10.1055/s-0028-1107053

Cited by 43 publications

(12 citation statements)

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“…Little thought was given to the possibility that such impairments might be restricted to a small subset of individuals who have a heightened risk of manifesting such deficits because of a particular constellation of disease-related variables. The latter possibility is consistent with results from several European electroencephalographic and neuropathological studies that identified serious hypoglycemic episodes (12,13) and poor metabolic control (14,15) as two variables that increased the likelihood of finding evidence of significant functional or structural central nervous system damage in diabetic children or young adults.…”

Section: Early Studies Of Intelligencesupporting

confidence: 83%

“…If the deleterious effects of repeated episodes of hypoglycemia are cumulative over time, in the same way that repeated episodes of alcohol intoxication apparently cumulate to produce a chronic intellectual impairment (46), evidence of intellectual dysfunction in adults who have repeatedly experienced low blood glucose levels would be expected. Second, both neuropsychological and electrophysiological investigations have reported relationships between past history of hypoglycemia and cognitive (1,2) or EEG (12,13) anomalies in children and adolescents. If such relationships can be demonstrated in younger diabetic patients, similar relationships in older patients should be apparent.…”

Section: Hypoglycemiamentioning

confidence: 98%

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Neurobehavioral Complications of Type I Diabetes: Examination of Possible Risk Factors

Ryan

1988

Diabetes Care

151

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There is increasing interest in the possibility that diabetes mellitus may be associated with a series of neurobehavioral, or neuropsychological, changes; i.e., learning, memory, problem solving, mental and motor speed, and eye-hand coordination may sometimes be disrupted in diabetic children and adults, and this disruption may be a consequence of certain disease-related variables. To date, four neurobehavioral risk factors have been identified. For children and adolescents, the most potent risk factors appear to be age at diagnosis and the occurrence of schoolroom-related problems. Children who develop diabetes early in life are more likely to show serious cognitive impairments on virtually all measures. In addition, diabetic children with school attendance problems tend to score lower than expected on verbal IQ tests and school achievement tests. For adults, the most carefully studied risk factor is degree of metabolic control. Adults in poor control are far more likely to manifest subtle changes on measures of mental efficiency. This may be particularly evident on tasks that require the development and deployment of sophisticated information-processing strategies. A fourth variable--severe episodes of hypoglycemia--is known to disrupt functioning in diabetic subjects of any age, although it has not yet been studied systematically in large-scale studies. Indeed, because virtually all extant studies have been based on limited neurobehavioral and biomedical assessments of relatively few volunteer subjects, this list of risk factors must be considered tentative at best.

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Section: Early Studies Of Intelligencesupporting

confidence: 83%

Section: Hypoglycemiamentioning

confidence: 98%

Neurobehavioral Complications of Type I Diabetes: Examination of Possible Risk Factors

Ryan

1988

Diabetes Care

151

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“…Many endocrinologists do not recommend intensive management of diabetes for young children because of the belief that intensive therapy is associated with a higher occurrence of hypoglycemia (1–7,17–21), and that hypoglycemia in young children is linked to decreased cognition and detrimental effects on the developing brain (10, 21–36). However, pediatric reports have shown that children who follow less intensive diabetes regimens and have relatively high HbA1c levels still have severe hypoglycemic events (35).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of glycemic control in young children with type 1 diabetes

et al. 2002

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“…Similarly, Ryan et al (6) reported that adolescents with diabetes were more likely to show nonspecific impairments on tests of cognitive and neuropsychological function if they developed diabetes before age 5 yr. They attributed this to a possible organic disturbance from multiple episodes of hypoglycemia, known to be more frequent and more difficult to control in very small children (9,10) as well as to produce abnormalities in brain function (11)(12)(13)(14)(15)(16).…”

mentioning

confidence: 98%

Intellectual Deficits Associated With Early Onset of Insulin-Dependent Diabetes Mellitus in Children

1987

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Twenty-seven children with early-onset (less than 4 yr) diabetes (EOD), 24 children with late-onset (greater than 4 yr) diabetes (LOD), and 30 sibling controls were compared in their performance on tests of intellectual functioning and school achievement. The results indicated that children with EOD, particularly girls, scored lower than the other groups of diabetic children and siblings on tests of visuospatial (P less than .05) but not verbal ability. Many of the girls with EOD were also having difficulty at school, and several were receiving special education. Children with EOD had more hypoglycemic convulsions than those with LOD. Both convulsions and age of onset were associated with poorer performance on spatial tasks. Girls with EOD had lower spatial test scores regardless of convulsion history, whereas boys with EOD scored lower only if they had had a convulsion.

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EEG-Veränderungen bei diabetischen Kindern

Cited by 43 publications

References 1 publication

Neurobehavioral Complications of Type I Diabetes: Examination of Possible Risk Factors

Neurobehavioral Complications of Type I Diabetes: Examination of Possible Risk Factors

Characteristics of glycemic control in young children with type 1 diabetes

Intellectual Deficits Associated With Early Onset of Insulin-Dependent Diabetes Mellitus in Children

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