2018
DOI: 10.1101/444281
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EEG signal diversity during propofol sedation: an increase in sedated but responsive, a decrease in sedated and unresponsive subjects

Abstract: Transitions between wakefulness and anesthesia are accompanied by profound changes in brain functioning. A key challenge is thus to disentangle neuronal mechanisms specific to loss and recovery of consciousness, from more general effects that are not directly related to the capacity for conscious experience. Measures of neuronal diversity have been recently proposed to constitute a robust correlate of the global states of consciousness. In the present study we investigated whether EEG signal diversity is indee… Show more

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Cited by 3 publications
(9 citation statements)
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“…To address this gap, we asked whether the connectivity within and between three networks that are primary sites of propofol-induced sedation and key to conscious cognition — the DAN, ECN and DMN — underlie individual responsiveness differences under anaesthesia. Consistent with previous studies (Chennu et al, 2016; Bola et al, 2019), we observed substantial individual differences in reaction times and hit rates under moderate anaesthesia. These were not related to differences in perceptual or high-level attention processes.…”
Section: Discussionsupporting
confidence: 92%
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“…To address this gap, we asked whether the connectivity within and between three networks that are primary sites of propofol-induced sedation and key to conscious cognition — the DAN, ECN and DMN — underlie individual responsiveness differences under anaesthesia. Consistent with previous studies (Chennu et al, 2016; Bola et al, 2019), we observed substantial individual differences in reaction times and hit rates under moderate anaesthesia. These were not related to differences in perceptual or high-level attention processes.…”
Section: Discussionsupporting
confidence: 92%
“…A first step to understanding consciousness is to define what it is 57 not. To this end, anaesthesia combined with functional neuroimaging provides a powerful 58 approach for studying the brain mechanisms that change as consciousness fades (Vatansever 59 during mild and moderate propofol anaesthesia reported that the participants' varying levels 78 of responsiveness were differentiated by alpha band connectivity during wakefulness 79 (Chennu et al, 2016), and changing patterns of EEG signal diversity from wakefulness to 80 moderate sedation (Bola et al, 2019). However, the brain regional-or network-bases for this these is related to individual differences in performance variability (Kelly 2008), and directly 116 supports sustained attention (Kucyi et al, 2020).…”
Section: Introduction 55mentioning
confidence: 99%
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“…The general correlations between LempeleZiv complexity and the spectral power of particular frequencies are to be expected based on simulations 20 and experimental reports. 29,30 However, we show that the increase in EEG complexity for high performance subjects is not the mere reflection of an increase (or decrease) of power within any particular frequency range. Instead, we propose it is based on modulation of the broad temporal dynamics of different brain processes.…”
Section: Discussionmentioning
confidence: 63%