EEG related neuronal activity in the pedunculopontine tegmental nucleus of urethane anaesthetized rats

Balatoni, Balázs; Détári, László

doi:10.1016/s0006-8993(02)03768-x

Cited by 21 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highly divergent nature of these projections suggests they are likely to exercise some form of general modulatory control over the appetitive and defensive functions of the SC (Scarnati and Florio, 1997; Balatoni and Detari, 2003). …”

Section: Discussionmentioning

confidence: 99%

Segregated Anatomical Input to Sub-Regions of the Rodent Superior Colliculus Associated with Approach and Defense

Comoli¹,

Favaro²,

Vautrelle³

et al. 2012

Front. Neuroanat.

139

122

View full text Add to dashboard Cite

The superior colliculus (SC) is responsible for sensorimotor transformations required to direct gaze toward or away from unexpected, biologically salient events. Significant changes in the external world are signaled to SC through primary multisensory afferents, spatially organized according to a retinotopic topography. For animals, where an unexpected event could indicate the presence of either predator or prey, early decisions to approach or avoid are particularly important. Rodents’ ecology dictates predators are most often detected initially as movements in upper visual field (mapped in medial SC), while appetitive stimuli are normally found in lower visual field (mapped in lateral SC). Our purpose was to exploit this functional segregation to reveal neural sites that can bias or modulate initial approach or avoidance responses. Small injections of Fluoro-Gold were made into medial or lateral sub-regions of intermediate and deep layers of SC (SCm/SCl). A remarkable segregation of input to these two functionally defined areas was found. (i) There were structures that projected only to SCm (e.g., specific cortical areas, lateral geniculate and suprageniculate thalamic nuclei, ventromedial and premammillary hypothalamic nuclei, and several brainstem areas) or SCl (e.g., primary somatosensory cortex representing upper body parts and vibrissae and parvicellular reticular nucleus in the brainstem). (ii) Other structures projected to both SCm and SCl but from topographically segregated populations of neurons (e.g., zona incerta and substantia nigra pars reticulata). (iii) There were a few brainstem areas in which retrogradely labeled neurons were spatially overlapping (e.g., pedunculopontine nucleus and locus coeruleus). These results indicate significantly more structures across the rat neuraxis are in a position to modulate defense responses evoked from SCm, and that neural mechanisms modulating SC-mediated defense or appetitive behavior are almost entirely segregated.

show abstract

Section: Discussionmentioning

confidence: 99%

Segregated Anatomical Input to Sub-Regions of the Rodent Superior Colliculus Associated with Approach and Defense

Comoli¹,

Favaro²,

Vautrelle³

et al. 2012

Front. Neuroanat.

139

122

View full text Add to dashboard Cite

show abstract

“…In urethane-anesthetized rats, the neocortical EEG shows periodic alternation between a slow-wave state and a fast-wave state (Detari et al, 1997;Balatoni and Detari, 2003;Murakami et al, 2005;Tsuno et al, 2008). The slow-wave state is characterized by high-amplitude, slow-wave oscillation and resembles the EEG pattern during slow-wave sleep.…”

Section: Oc-spws Occur During the Slow-wave State Under Urethane Anesmentioning

confidence: 99%

Olfactory Cortex Generates Synchronized Top-Down Inputs to the Olfactory Bulb during Slow-Wave Sleep

Manabe¹,

Kusumoto-Yoshida²,

Ota³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

The olfactory cortex is functionally isolated from the external odor world during slow-wave sleep. However, the neuronal activity pattern in the olfactory cortex and its functional roles during slow-wave sleep are not well understood. Here, we demonstrate in freely behaving rats that the anterior piriform cortex, a major area of the olfactory cortex, repeatedly generates sharp waves that are accompanied by synchronized discharges of numerous cortical neurons. Olfactory cortex sharp waves occurred relatively independently of hippocampal sharp waves. Current source density analysis showed that sharp wave generation involved the participation of recurrent association fiber synapses to pyramidal cells in the olfactory cortex. During slow-wave sleep, the olfactory bulb showed sharp waves that were in synchrony with olfactory cortex sharp waves, indicating that olfactory cortex sharp waves drove synchronized top-down inputs to the olfactory bulb. Based on these results, we speculate that the olfactory cortex sharp waves may play a role in the reorganization of bulbar neuronal circuits during slow-wave sleep.

show abstract

“…Under urethane anesthesia, the cortical EEG shows a periodic alternation between a slow-wave state (SWS) and a fast-wave state (FWS) (Détári et al, 1997;Balatoni and Détári, 2003;Murakami et al, 2005). The former resembles the EEG pattern during the slowwave sleep state, and the latter corresponds to the shallower stage of anesthesia stage III-3 of the Guedel stage of anesthesia (Friedberg et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Behavioral State Regulation of Dendrodendritic Synaptic Inhibition in the Olfactory Bulb

Tsuno¹,

Kashiwadani²,

Mori³

2008

J. Neurosci.

View full text Add to dashboard Cite

Behavioral states regulate how information is processed in local neuronal circuits. Here, we asked whether dendrodendritic synaptic interactions in the olfactory bulb vary with brain and behavioral states. To examine the state-dependent change of the dendrodendritic synaptic transmission, we monitored changes in field potential responses in the olfactory bulb of urethane-anesthetized and freely behaving rats. In urethane-anesthetized rats, granule-to-mitral dendrodendritic synaptic inhibition was larger and longer when slow waves were present in the electroencephalogram (slow-wave state) than during the fast-wave state. The state-dependent alternating change in the granule-to-mitral inhibition was regulated by the cholinergic system. In addition, the frequency of the spontaneous oscillatory activity of local field potentials and periodic discharges of mitral cells in the olfactory bulb shifted in synchrony with shifts in the neocortical brain state. Freely behaving rats showed multilevel changes in dendrodendritic synaptic inhibition that corresponded to diverse behavioral states; the inhibition was the largest during slow-wave sleep state, and successively smaller during light sleep, awake immobility, and awake moving states. These results provide evidence that behavioral state-dependent global changes in cholinergic tone modulate dendrodendritic synaptic inhibition and the information processing mode in the olfactory bulb.

show abstract

EEG related neuronal activity in the pedunculopontine tegmental nucleus of urethane anaesthetized rats

Cited by 21 publications

References 35 publications

Segregated Anatomical Input to Sub-Regions of the Rodent Superior Colliculus Associated with Approach and Defense

Segregated Anatomical Input to Sub-Regions of the Rodent Superior Colliculus Associated with Approach and Defense

Olfactory Cortex Generates Synchronized Top-Down Inputs to the Olfactory Bulb during Slow-Wave Sleep

Behavioral State Regulation of Dendrodendritic Synaptic Inhibition in the Olfactory Bulb

Contact Info

Product

Resources

About