EEG power spectrum differences in early and late onset forms of Alzheimer's disease

Pucci, Eugenio; Belardinelli, Natascia; Cacchiò, Gabriella; Signorino, Mario; Angeleri, F

doi:10.1016/s1388-2457(98)00054-6

Cited by 66 publications

(36 citation statements)

References 44 publications

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“…In our sample the group of patients with focal and diffuse abnormalities were younger than the other groups of patients. This is in line with studies that found more EEG abnormalities in younger patients [25,26]. …”

Section: Discussionsupporting

confidence: 93%

EEG Abnormalities Are Associated with Different Cognitive Profiles in Alzheimer’s Disease

Smits

Liedorp

Koene³

et al. 2010

Dement Geriatr Cogn Disord

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Objective: Our purpose was to investigate associations between different cognitive profiles and their underlying functional brain changes as measured by electroencephalogram (EEG) in Alzheimer’s disease (AD). Methods: EEG was obtained and neuropsychological performance assessed in 254 patients with AD. The EEGs were visually assessed for the presence of focal and/or diffuse abnormalities. Multivariate analysis of variance for repeated measures was performed with presence of focal and/or diffuse abnormalities as between-subjects factor and neuropsychological tests as within-subject factor. Age, sex and education were entered as covariates. Results: Twenty-eight percent of the patients had a normal EEG, 32% had focal abnormalities, 14% diffuse abnormalities and 26% had both focal and diffuse abnormalities. Patients with a normal EEG presented with a cognitive profile in which memory was mostly impaired. Patients with focal and diffuse EEG abnormalities presented with a nonmemory profile. Conclusion: These results illustrate that specific types of EEG abnormalities are associated with different cognitive profiles in AD, providing biological support in terms of brain functioning for variability in cognitive impairment.

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Section: Discussionsupporting

confidence: 93%

EEG Abnormalities Are Associated with Different Cognitive Profiles in Alzheimer’s Disease

Smits

Liedorp

Koene³

et al. 2010

Dement Geriatr Cogn Disord

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“…Of note, EEG recordings lasting 5 min allow the comparison of the current results with several previous AD studies also using recording EEG periods not longer than 5 min (Buchan et al, 1997;Pucci et al, 1999) or even shorter than 1 min (Dierks et al, 1993. In particular, this protocol has been successful in a previous reference study of long-term donepezil effects on scalp EEG in AD patients (Rodriguez et al, 2002).…”

Section: Eeg Recordingsmentioning

confidence: 56%

Donepezil effects on sources of cortical rhythms in mild Alzheimer's disease: Responders vs. Non-Responders

Cassetta²,

et al. 2006

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“…The approach to divide slow frequencies and dominant activity is still a matter of debate in dementia. In fact, whereas some authors prefer to maintain the classical band division [21][22][23], others [10,24,34,35,38] suggest lowering the limit because they consider that the faster waves just represent a slowing down of the · activity in these cases [39]. In keeping with these last authors, we preferred to attribute all frequencies belonging to the principal EEG rhythm to the same band rather than to split them into two different bands with a very different clinical meaning.…”

Section: Discussionmentioning

confidence: 97%

“…The choice of these 2 qEEG bands takes into account the 'shift to the left' of the background activity in AD patients even in the mild or moderate phases of the disease [18]. The frequency range of background activity was then fixed at 6.5-12.0 Hz according to the suggestions of others [24,34,35]. Four brain regions were identified by averaging log-transform values of the two frequency bands between F3-F7 (left frontal region), F4-F8 (right frontal region), P3-T5 (left temporoparietal region), P4-T6 (right temporoparietal region).…”

Section: Quantitative Eegmentioning

confidence: 99%

Quantitative EEG Changes in Alzheimer Patients during Long-Term Donepezil Therapy

Rodriguez¹,

Vitali²,

Leo³

et al. 2002

Neuropsychobiology

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Twenty patients affected with probable mild-to-moderate Alzheimer’s disease (AD; NINCDS-ADRDA criteria; 14 women and 6 men, mean age 75.2 ± 7.1 years) who regularly received an oral acetylcholinesterase inhibitor (AChEI; donepezil 5 mg/day; Dz group) were compared with a control group of 11 AD patients (6 women and 5 men, mean age 73.5 ± 6.0 years) diagnosed and followed up in the pre-AChEIs era (C group). At basal evaluation (t₀), the 2 groups were comparable for age, education, and severity of disease (Global Deterioration Scale). All patients underwent quantitative EEG (qEEG, average reference, 10–20 International System), and were reexamined about 1 year later (t₁; i.e., after 12.3 ± 3.6 months the Dz group, and after 13.7 ± 3.9 months the C group). Log-transformed values of two qEEG bands, i.e. 2–6 and 6.5–12 Hz, were averaged between adjacent channels (frontal F3 and F7, F4 and F8; parietotemporal P3 and T7, P4 and T8) to obtain a qEEG ratio (6.5–12/2–6 Hz.) from one frontal and one temporoparietal region in each hemisphere. Neuropsychological impairment was summarized by the Mini-Mental Status Examination (MMSE). At t₀, both the MMSE score and the qEEG ratio values were somewhat higher in the C than in the Dz group, although nonsignificantly. Between t₀ and t₁, the MMSE score decreased significantly (p < 0.01) more in the C group (–4.36 ± 2.25) than in the Dz group (–1.45 ± 2.16), as did the qEEG ratio in the right frontal region (p < 0.01), whereas in the left frontal region the significance level was not reached (p = 0.02). Between t₀ and t₁, the qEEG ratio difference in both frontal regions and in the right temporoparietal region significantly correlated with the MMSE difference (p < 0.01), but neither with time between examinations nor with the difference on the Visual Search Test score. Long-term treatment with Dz led to a lesser deterioration of qEEG, paralleling a milder neuropsychological decline. The effect was significant in frontal regions, possibly because they are relatively spared during the mild-to-moderate phases of the disease.

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EEG power spectrum differences in early and late onset forms of Alzheimer's disease

Cited by 66 publications

References 44 publications

EEG Abnormalities Are Associated with Different Cognitive Profiles in Alzheimer’s Disease

EEG Abnormalities Are Associated with Different Cognitive Profiles in Alzheimer’s Disease

Donepezil effects on sources of cortical rhythms in mild Alzheimer's disease: Responders vs. Non-Responders

Quantitative EEG Changes in Alzheimer Patients during Long-Term Donepezil Therapy

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