EEG markers of pain suppression as a result of electrical stimulation: case report

Kleeva, Daria; Lebedev, Mikhail; Biktimirov, Artur; Matvienko, Yu. G.; Sintsov, Mikhail; Piliugin, Nikita; Soghoyan, Gurgen

doi:10.1109/cnn56452.2022.9912563

Cited by 1 publication

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“…Also, the objective representation of stimulation can be used for a closed-loop neurostimulation that will adjust stimulation amplitude to cause the required level of perceived sensation. Previously we suggested using EEG biomarkers to adjust stimulation for the treatment of PLP (Kleeva et al, 2022).…”

Section: Eegmentioning

confidence: 99%

“…PNS and SCS suppress PLP by inhibiting the effects of the pathological discharges generated in the neuromas and affecting the spinal (10) and cortical (11) activity. A preferred neurostimulation system for the amputees would be a bidirectional one where stimulation parameters are set based on PLP-related changes in neural activity (12). In addition to PNS and SCS, such a system could incorporate transcutaneous electrical nerve stimulation (TENS) (13) and targeted muscle reinnervation (TMR) (14).…”

Section: Introductionmentioning

confidence: 99%

“…While the pain-relieving mechanisms of PNS and SCS are not fully understood, it has been suggested that they could inhibit pathological patterns of activity generated by neuromas both at the spinal (Foell et al, 2011) and cortical levels (Zheng et al, 2021). An optimal neurostimulation system for amputees would be a bidirectional one where stimulation parameters are set based on changes in neural activity (Kleeva et al, 2022). In addition to PNS and SCS, such a system could incorporate transcutaneous electrical nerve stimulation (TENS) (Flor et al, 2001) and targeted muscle reinnervation (TMR) (Mioton et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Restoration of Natural Somatic Sensations to the Amputees: Finding the Right Combination of Neurostimulation Methods

Soghoyan

Biktimirov

Piliugin

et al. 2023

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Limb amputation results in such devastating consequences as loss of motor and sensory functions and phantom limb pain (PLP). Here we explored peripheral nerve stimulation (PNS), spinal cord stimulation (SCS) and transcutaneous electrical nerve stimulation (TENS) as the approaches to enable tactile and proprioceptive sensations in amputees, and suppress PLP. We investigated the efficacy of these approaches for sensory discrimination tasks, namely determining object size and softness using a bionic prosthesis of the hand. Two transhumeral amputees were implanted for four weeks with stimulating electrodes placed in the medial nerve and/or epidurally over the spinal cord. Both PNS and SCS mapped to the sensation in different parts of the phantom hand, which was confirmed by both subjective reports and electroencephalographic (EEG) recordings of cortical responses to stimulation. Surprisingly, PNS provided more naturalistic sensations compared to SNS. Moreover, these sensations were felt as emerging from the prosthetic hand when the participants performed sensorimotor tasks where they determined the size and softness of objects being grasped. As they practiced in these tasks, the prosthetic sensations became more natural. While the participants could perform some of the tasks, for example tactile surface exploration, using auditory feedback, PNS and/or SCS have a benefit of better approximating the sensations lost to the amputation while suppressing PLP.

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Section: Eegmentioning

confidence: 99%