EEG markers and subjective memory complaints in young and older people

Pérez, Vicente M. Simón; Garrido-Chaves, Ruth; Zapater-Fajarí, Mariola; Pulopulos, Matías M.; Hidalgo, Vanesa; Salvador, Alicia

doi:10.1016/j.ijpsycho.2022.09.006

Cited by 11 publications

(5 citation statements)

References 65 publications

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“…The study showed that electroencephalographic oscillatory responses in theta power and phase-locking during a standard visual oddball paradigm probing visual focused attention and short-term memory may be suitable biomarkers to investigate working cognitive brain systems in both groups of patients. Results obtained by Perez et al, 2022 [ 215 ] confirm previous evidence showing that older people with subjective memory complaints are characterized by distinct power resting state EEG rhythms, especially at increased theta power. These authors propose that electrophysiological biomarkers of brain dysfunction may identify cognitive decline before they are observed in a neuropsychological assessment.…”

Section: Theta Rhythms Alterations In Dementias Including Adsupporting

confidence: 77%

“…Theta waves have been proposed as potential electrophysiological biomarkers for neurocognitive impairments, allowing early identification before neuropsychological assessments [209][210][211]215]. However, the therapeutic efficacy of HCN channel agonists in memory decline and dementia, along with their impact on theta parameters, remains unclear due to discrepancies in the literature and limited data.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations

2024

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Increasing evidence indicates a role of hyperpolarization activated cation (HCN) channels in controlling the resting membrane potential, pacemaker activity, memory formation, sleep, and arousal. Their disfunction may be associated with the development of epilepsy and age-related memory decline. Neuronal hyperexcitability involved in epileptogenesis and EEG desynchronization occur in the course of dementia in human Alzheimer’s Disease (AD) and animal models, nevertheless the underlying ionic and cellular mechanisms of these effects are not well understood. Some suggest that theta rhythms involved in memory formation could be used as a marker of memory disturbances in the course of neurogenerative diseases, including AD. This review focusses on the interplay between hyperpolarization HCN channels, theta oscillations, memory formation and their role(s) in dementias, including AD. While individually, each of these factors have been linked to each other with strong supportive evidence, we hope here to expand this linkage to a more inclusive picture. Thus, HCN channels could provide a molecular target for developing new therapeutic agents for preventing and/or treating dementia.

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Section: Theta Rhythms Alterations In Dementias Including Adsupporting

confidence: 77%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations

2024

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“…In addition, clinicians struggle to discern which patients with subjective memory complaints (SMCs) have true memory disorders. A study of patients with SMCs revealed significantly increased spectral theta density power and loss of central alpha reactivity with eye opening for older adults compared with younger subjects [ 41 ]. An elevated theta band power magnitude was positively correlated with degree of verbal memory loss.…”

Section: Eeg Studies Of Neurological and Behavioral Disordersmentioning

confidence: 99%

Sub-Scalp Implantable Telemetric EEG (SITE) for the Management of Neurological and Behavioral Disorders beyond Epilepsy

Pacia

2023

Brain Sciences

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Sub-scalp Implantable Telemetric EEG (SITE) devices are under development for the treatment of epilepsy. However, beyond epilepsy, continuous EEG analysis could revolutionize the management of patients suffering from all types of brain disorders. This article reviews decades of foundational EEG research, collected from short-term routine EEG studies of common neurological and behavioral disorders, that may guide future SITE management and research. Established quantitative EEG methods, like spectral EEG power density calculation combined with state-of-the-art machine learning techniques applied to SITE data, can identify new EEG biomarkers of neurological disease. From distinguishing syncopal events from seizures to predicting the risk of dementia, SITE-derived EEG biomarkers can provide clinicians with real-time information about diagnosis, treatment response, and disease progression.

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“…Studies examining the neurophysiologic basis of subjective cognitive complaints in other populations report a similar pattern: higher delta and lower alpha activities differentiate older adults with subjective memory problems from healthy controls (26). Furthermore, the positive relationship between complaints and theta power in EEG (27) and MRI abnormalities (28) is more pronounced in the older adults and TBI groups. In conclusion, it appears that subjective cognitive problems and acute mTBI share a neurophysiology of higher deltatheta power and lower alpha, and this has not been systematically examined in the chronic phase.…”

Section: Eeg Spectra and Subjective Cognitive Complaintsmentioning

confidence: 99%

Long-term resting EEG correlates of repetitive mild traumatic brain injury and loss of consciousness: alterations in alpha-beta power

Franke,

Perera,

Sponheim

2023

Front. Neurol.

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ObjectiveLong-term changes to EEG spectra after mild traumatic brain injury (mTBI, i.e., concussion) have been reported; however, the role of injury characteristics in long-term EEG changes is unclear. It is also unclear how any chronic EEG changes may underlie either subjective or objective cognitive difficulties, which might help explain the variability in recovery after mTBI.MethodsThis study included resting-state high-density electroencephalography (EEG) and mTBI injury data from 340 service members and veterans collected on average 11 years after injury as well as measures of objective and subjective cognitive functioning. The average absolute power within standard bands was computed across 11 spatial regions of the scalp. To determine how variation in brain function was accounted for by injury characteristics and aspects of cognition, we used regression analyses to investigate how EEG power was predicted by mTBI history characteristics [number, number with post-traumatic amnesia and witnessed loss of consciousness (PTA + LOC), context of injury (combat or non-combat), potentially concussive blast exposures], subjective complaints (TBIQOL General Cognitive and Executive Function Concerns), and cognitive performance (NIH Toolbox Fluid Intelligence and premorbid IQ).ResultsPost-traumatic amnesia (PTA) and loss of consciousness (LOC), poorer cognitive performance, and combat experience were associated with reduced power in beta frequencies. Executive function complaints, lower premorbid IQ, poorer cognitive performance, and higher psychological distress symptoms were associated with greater power of delta frequencies. Multiple regression confirmed the relationship between PTA + LOC, poor cognitive performance, cognitive complaints, and reduced power in beta frequencies and revealed that repetitive mTBI was associated with a higher power in alpha and beta frequencies. By contrast, neither dichotomous classification of the presence and absence of mTBI history nor blast exposures showed a relationship with EEG power variables.ConclusionLong-term alterations in resting EEG spectra measures of brain function do not appear to reflect any lasting effect of a history of mTBI or blast exposures. However, power in higher frequencies reflects both injury characteristics and subjective and objective cognitive difficulties, while power in lower frequencies is related to cognitive functions and psychological distress associated with poor long-term outcomes after mTBI.

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EEG markers and subjective memory complaints in young and older people

Cited by 11 publications

References 65 publications

Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations

Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations

Sub-Scalp Implantable Telemetric EEG (SITE) for the Management of Neurological and Behavioral Disorders beyond Epilepsy

Long-term resting EEG correlates of repetitive mild traumatic brain injury and loss of consciousness: alterations in alpha-beta power

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