EEG indices of tonic pain-related activity in the somatosensory cortices

Dowman, Robert; Rissacher, Daniel J.; Schuckers, Stephanie

doi:10.1016/j.clinph.2008.01.019

Cited by 93 publications

(98 citation statements)

References 76 publications

(97 reference statements)

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“…Two published studies interpreted the pain induced gamma enhancement as related to muscle artifacts [12,41]. The intramuscular infusion could lead to an increase in baseline EMG activity.…”

Section: Discussionmentioning

confidence: 98%

“…Studies investigating tonic cutaneous pain reported inconsistent findings, most of them reported pain-induced suppression of alpha oscillations in frontal-central, temporal or parietal-occipital regions [12,13,24], while a few reported pain-induced enhancement of alpha oscillations [11,25] and gamma oscillations [14]. However, pain-related EEG changes to tonic deep pain were rarely reported, and the similarity and difference of cortical processing to tonic cutaneous pain and tonic deep pain remains unclear.…”

Section: Introductionmentioning

confidence: 92%

“…Besides, different from pain originating from deep tissue, cutaneous pain is not dominantly encountered in clinical practice [5,6]. Currently, tonic cutaneous pain models (e.g., cold pain [7][8][9][10][11][12], tonic heat pain [13][14][15][16][17]) have been proposed to resemble clinical pain, and to investigate pain-related cortical features [5,18]. There is growing interest in elucidating the neural correlates of tonic deep pain using various physical stressors: muscular injections of capsaicin [19,20] and hypertonic saline [21].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Changes of gamma-band oscillatory activity to tonic muscle pain

Liu

Cai

et al. 2016

Neuroscience Letters

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“…Two published studies interpreted the pain induced gamma enhancement as related to muscle artifacts [12,41]. The intramuscular infusion could lead to an increase in baseline EMG activity.…”

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Changes of gamma-band oscillatory activity to tonic muscle pain

Liu

Cai

et al. 2016

Neuroscience Letters

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“…Previous imaging studies have shown increased neuronal activities in these regions under chronic pain conditions (Apkarian et al 2005(Apkarian et al , 2009Brooks and Tracey 2005;Ohara et al 2005), and reduced overactivation during pain relief (Prichep et al 2011;Stern et al 2006). Similarly, multiple brain regions in the pain matrix showed stronger oscillatory activities in the higher frequency range ([12 Hz) but decreased low frequency oscillations (\12 Hz) during noxious stimulation (Dowman et al 2008;Iwata et al 2005;Ploner et al 2006;Shao et al 2012). Thus, it is rational to propose that moxibustion exerts its therapeutic effects through insula-centered cortical circuits.…”

Section: Discussionmentioning

confidence: 99%

Cortical activities of heat-sensitization responses in suspended moxibustion: an EEG source analysis with sLORETA

Wang

Zhang

et al. 2015

Cogn Neurodyn

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Moxibustion is under active research as a complementary and alternative treatment for various diseases such as pain. ''Heat-sensitization'' responses have been reported during suspended moxibustion, whose occurrence is associated with significantly better therapeutic effects. The present study aimed to investigate the cortical activities of this interesting phenomenon by a standardized low-resolution brain electromagnetic tomography. We performed electroencephalography recording in a group of patients with chronic low back pain before, during, and after moxibustion treatment at Yaoyangguan (DU3) areas. 11 out of 21 subjects experienced strong heatsensitization during moxibustion, which were accompanied with significant decreases of current densities in the beta frequency bands in prefrontal, primary and second somatosensory, and cingulate cortices, as well as increased current densities in the alpha2 band in the left insula. No changes were detected in patients without sensitization responses, or in the post-moxibustion phase of either group. These data indicated widespread activity changes across different frequency bands during heat-sensitization. Cortical oscillatory activities could be used to evaluate the ''heatsensitization'' responses during suspended moxibustion.

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“…However, when looking at the relative change for the discriminative channel (C6), we also saw a correlation between this decrease in alpha activity and the analgesic effect. Decreased alpha activity has also been associated with painful stimulation [34], and it seems paradoxical that a proven analgesic treatment would influence brain oscillations in the same manner as painful stimulation.…”

Section: Clinical Correlations Of the Eegmentioning

confidence: 99%

Altered Frequency Distribution in the Electroencephalogram is Correlated to the Analgesic Effect of Remifentanil

Graversen

Malver

Kurita

et al. 2014

Basic Clin Pharma Tox

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Opioids alter resting state brain oscillations by multiple and complex factors, which are still to be elucidated. To increase our knowledge, multi-channel electroencephalography (EEG) was subjected to multivariate pattern analysis (MVPA), to identify the most descriptive frequency bands and scalp locations altered by remifentanil in healthy volunteers. Sixty-two channels of resting EEG followed by independent measures of pain scores to heat and bone pain were recorded in 21 healthy males before and during remifentanil infusion in a placebo-controlled, double-blind crossover study. EEG frequency distributions were extracted by a continuous wavelet transform and normalized into delta, theta, alpha, beta and gamma bands. Alterations relative to pre-treatment responses were calculated for all channels and used as input to the MVPA. Compared to placebo, remifentanil increased the delta band and decreased the theta and alpha band oscillations as a mean over all channels (all p ≤ 0.007). The most discriminative channels in these frequency bands were F1 in delta (83.33%, p = 0.0023) and theta bands (95.24%, p < 0.0001), and C6 in the alpha band (80.95%, p = 0.0054). These alterations were correlated to individual changes in heat pain in the delta (p = 0.045), theta (p = 0.038) and alpha (p = 0.039) bands and to bone pain in the alpha band (p = 0.0092). Hence, MVPA of multi-channel EEG was able to identify frequency bands and corresponding channels most sensitive to altered brain activity during remifentanil treatment. As the EEG alterations were correlated to the analgesic effect, the approach may prove to be a novel methodology for monitoring individual efficacy to opioids.Remifentanil is a selective l-receptor opioid agonist with short onset and duration of action [1,2]. This provides a remarkable titratability, which has proved useful for balanced anaesthesia and analgosedation as well as scientific research in experimental and clinical settings [3]. For scientific research on the underlying mechanisms of action of remifentanil, electroencephalography (EEG) provides information about the time course of electrical activity in the brain. This has been investigated in several previous studies, and the results indicate a relationship between EEG changes and the potency of remifentanil [4,5]. However, although the results of these studies have shed light on many of the underlying mechanisms of remifentanil, data are conflicting and the linkage between altered brain activity and the analgesic effect of remifentanil still remains unclear.Elucidation of the association between pain stimulation/measurement and altered EEG characteristics is therefore warranted. This could be accomplished in a placebo-controlled, crossover study in healthy volunteers treated with low-dose remifentanil, which enables comparison of EEG alterations during remifentanil treatment in comparison with alterations during placebo therapy. In such a low-dose set-up, the healthy volunteer would still be conscious and able to rate pain sensations...

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EEG indices of tonic pain-related activity in the somatosensory cortices

Abstract: This study identified several factors that need to be controlled and/or isolated in order to successfully record EEG features that index pain-related activity in the somatosensory cortices.

Cited by 93 publications

References 76 publications

Changes of gamma-band oscillatory activity to tonic muscle pain

Changes of gamma-band oscillatory activity to tonic muscle pain

Cortical activities of heat-sensitization responses in suspended moxibustion: an EEG source analysis with sLORETA

Altered Frequency Distribution in the Electroencephalogram is Correlated to the Analgesic Effect of Remifentanil

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