EEG functional connectivity in term age extremely low birth weight infants

Grieve, Philip G.; Isler, Joseph R.; Izraelit, Asya; Peterson, Bradley S.; Fifer, William P.; Myers, Michael; Stark, Raymond I.

doi:10.1016/j.clinph.2008.09.020

Cited by 61 publications

(63 citation statements)

References 73 publications

(90 reference statements)

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“…Even though recent histological and MRI studies have enabled to highlight part of these mechanisms, the story is just beginning notably to understand how this development may be impacted by genetic, epigenetic, and environmental factors or early disturbances (e.g., in utero growth, preterm birth, hypoxic-ischemic lesion, neonatal stroke, and postnatal environment) (Ball et al, 2014;Fischi-Gomez et al, 2014;Gao et al, 2014;Grieve et al, 2008;Smyser et al, 2013). Despite challenges to studying fetuses and infants, combining complementary postmortem and in vivo approaches should provide a great opportunity to investigate the developing brain at different scales, from microstructure to functional organization.…”

Section: Resultsmentioning

confidence: 99%

Development of Structural and Functional Connectivity

Dubois¹,

Kostović²,

Judaš³

2015

Brain Mapping

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Elsevier Inc. All rights reserved. GlossaryFiber myelination brain maturational mechanism corresponding to the ensheathment around neuronal axons of oligodendrocytes' processes that form the myelin sheaths. It leads to an increase in the conduction speed of the nerve impulse and progresses from the second part of pregnancy to the end of adolescence with a specific calendar across white matter bundles and cerebral regions.Subplate transient cerebral compartment containing the most differentiated postmigratory neurons, observed between the intermediate zone (fetal white matter) and the cortical plate between 13 PCW and around term age (still observed in the first postnatal months in some frontal association regions). AbbreviationsAF Arcuate fasciculus ALIC Anterior limb of the internal capsule CC Corpus callosum (g/b/s, genu/body/splenium) CG Cingulum (inf/sup, inferior/superior parts) CST Corticospinal tract (inf/mid/sup, inferior/middle/ superior portions) DSI Diffusion spectrum imaging DTI Diffusion tensor imaging DWI Diffusion-weighted imaging EC External capsule EEG Electroencephalography ERP Event-related potentials FA Fractional anisotropy fcMRI Functional connectivity MRI FX Fornix GA Gestational age GM Gray matter iFOF Inferior fronto-occipital fasciculus ILF Inferior longitudinal fasciculus MD Mean diffusivity MRI Magnetic resonance imaging OR Optic radiations PCW Postconceptional weeks SLF Superior longitudinal fasciculus STT Spinothalamic tract T 1 Longitudinal relaxation time T 1 w T 1 -weighted T 2 Transverse relaxation time T 2 w T 2 -weighted UF Uncinate fasciculus w GA Weeks of gestational age IntroductionDuring the early fetal period, there are few axonal pathways and synaptic connections already established in the human brain. Thus, starting with this period, we have a unique opportunity to follow the step-by-step, complex, but sequential development of cerebral connectivity, until all major connections become established in the late fetal (preterm) period. Even though the pathways' connectivity and the cortical circuitry are not fully established yet in preterm newborns, brain regions are organized early on into networks specialized to process sensorimotor and cognitive functions (Mahmoudzadeh et al., 2013). These functional networks further develop, mature, and refine until the end of adolescence. In this article, we aim to describe the early development of connectivity, from the fetal to the postnatal periods, as mapped in postmortem histological studies and in vivo MRI studies of fetuses, newborns, and infants. We successively detail (1) how the structural connectivity first develops, (2) how the white matter pathways then become myelinated and functionally mature, and (3) how functional connectivity emerges in the course of development.

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Section: Resultsmentioning

confidence: 99%

Development of Structural and Functional Connectivity

Dubois¹,

Kostović²,

Judaš³

2015

Brain Mapping

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“…Brain damage can still bring delayed cognitive, motor and sensory system dysfunction. Indeed, more than 50% of children and adolescents born preterm have needed the support of special education and monitoring by mental health services throughout their life 5,6,7 . While NICU is essential for the survival of newborns, the invasive environment, constant exposure to light, high noise level and noxious interventions generate stimuli that overload and damage the sensory system, and may have deleterious effects, changing the immature brain and its further development.…”

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confidence: 99%

Sleep deprivation, pain and prematurity: a review study

Bonan

Filho

Tristão

et al. 2015

Arq. Neuro-Psiquiatr.

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The aim was to describe current reports in the scientific literature on sleep in the intensive care environment and sleep deprivation associated with painful experiences in premature infant. A systematic search was conducted for studies on sleep, pain, premature birth and care of the newborn. Web of Knowledge, MEDLINE, LILACS, Cochrane Library, PubMed, EMBASE, Scopus, VHL and SciELO databases were consulted. The association between sleep deprivation and pain generates effects that are observed in the brain and the behavioral and physiological activity of preterm infants. Polysomnography in intensive care units and pain management in neonates allow comparison with the first year of life and term infants. We have found few references and evidence that neonatal care programs can influence sleep development and reduce the negative impact of the environment. This evidence is discussed from the perspective of how hospital intervention can improve the development of premature infants.Keywords: sleep, pain, prematurity, polysomnography, neonatal intensive care.RESUMO O objetivo foi descrever o estado atual na literatura científica sobre privação do sono associado a experiências dolorosas no prematuro e o papel na evolução do sono em ambiente de terapia intensiva. Realizou-se uma busca sistemática para estudos sobre sono, dor, prematuridade e programas de atenção ao neonato. Foram consultados as bases Web-of-Knowledge, MEDLINE, LILACS, Biblioteca Cochrane, PubMed, EMBASE, Scopus, BVS e SciELO. A associação entre privação do sono e dor gera efeitos que são observados na atividade cerebral, fisiológica e comportamental dos prematuros. A polissonografia nas unidades intensivas e o manejo da dor em neonatos permitem comparação no primeiro ano de vida com crianças nascidas a termo. Encontraram-se poucas evidências de que programas de cuidado neonatal podem influenciar o desenvolvimento do sono e diminuir o impacto negativo do ambiente. Estas evidências são discutidas na perspectiva de como a intervenção hospitalar pode melhorar o desenvolvimento do prematuro.Palavras-chave: sono, dor, prematuridade, polissonografia, terapia intensiva neonatal.In recent decades there has been a considerable increase in the number of premature births and in the survival rate of these babies as a consequence of also increasing the effectiveness of intervention in Neonatal Intensive Care Unit (NICU). This relatively recent phenomenon has opened various fronts of research on the development of the fetus outside the uterus and its challenges. Among the areas that have aroused more interest and generated publications are the investigations on the development of sleep and pain perception and the future implications of sleep deprivation and exposure to pain at early ages. The uterine environment is suitable for the full growth and development of the human fetus site. The challenge of preterm birth and hospitalization in the NICU promotes an abrupt environmental difference for newborns which can bring challenges for future development. The inst...

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“…The introduction of novel dense array EEG recording methods (30-130 electrodes) into neonatal work has opened the possibility to study spatial details in neonatal brain activity in both hospital and laboratory settings (Grieve et al, 2008;Odabaee et al, 2013;Omidvarnia et al, 2014;Tokariev et al, 2012;Wallois et al, 2009). The recent theoretical work has shown that the information content, or spatial richness, of EEG signal that can be recorded from the neonatal scalp is dramatically higher than what is conventionally thought (Grieve et al, 2003(Grieve et al, , 2004Odabaee et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…The conventional EEG analysis often relies on using variations of bipolar, linked mastoid reference or average reference montages, while the more recent, academically oriented studies (cf. Grieve et al, 2008;Omidvarnia et al, 2014;Roche-Labarbe et al, 2008;Tokariev et al, 2012) commonly rely on average and CSD montages. Our results show clearly that mixing signals results in a significant loss of specificity and sensitivity about spatial interactions, as in bipolar derivations, including common Cz reference.…”

Section: Effects Of Analysis Montagementioning

confidence: 99%

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Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage

Tokariev

Vanhatalo

Palva

2016

Clinical Neurophysiology

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Dense array EEG Connectivity Brain development h i g h l i g h t sAnalysis of brain connectivity from the neonatal EEG is strongly enhanced by adding the number of electrodes. Sensitivity and specificity of cortical synchrony estimates depend on the analysis montage; average and Laplacian montage have the best performance. The number of electrodes defines the optimal montage and it also sets the limits for the level of analytic details. a b s t r a c tObjective: To assess how the recording montage in the neonatal EEG influences the detection of cortical source signals and their phase interactions. Methods: Scalp EEG was simulated by forward modeling 20-200 simultaneously active sources covering the cortical surface of a realistic neonatal head model. We assessed systematically how the number of scalp electrodes (11-85), analysis montage, or the size of cortical sources affect the detection of cortical phase synchrony. Statistical metrics were developed for quantifying the resolution and reliability of the montages. Results: The findings converge to show that an increase in the number of recording electrodes leads to a systematic improvement in the detection of true cortical phase synchrony. While there is always a ceiling effect with respect to discernible cortical details, we show that the average and Laplacian montages exhibit superior specificity and sensitivity as compared to other conventional montages. Conclusions: Reliability in assessing true neonatal cortical synchrony is directly related to the choice of EEG recording and analysis configurations. Because of the high conductivity of the neonatal skull, the conventional neonatal EEG recordings are spatially far too sparse for pertinent studies, and this loss of information cannot be recovered by re-montaging during analysis. Significance: Future neonatal EEG studies will need prospective planning of recording configuration to allow analysis of spatial details required by each study question. Our findings also advice about the level of details in brain synchrony that can be studied with existing datasets or by using conventional EEG recordings.

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EEG functional connectivity in term age extremely low birth weight infants

Cited by 61 publications

References 73 publications

Development of Structural and Functional Connectivity

Development of Structural and Functional Connectivity

Sleep deprivation, pain and prematurity: a review study

Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage

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