EEG correlates of the severity of posttraumatic stress symptoms: A systematic review of the dimensional PTSD literature

Lobo, Isabela; Portugal, Liana Catarina Lima; Figueira, Ivan; Volchan, Eliane; David, Isabel A.; Pereira, Mirtes Garcia; Oliveira, Letícia

doi:10.1016/j.jad.2015.05.015

Cited by 78 publications

(46 citation statements)

References 89 publications

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“…Another recent study utilizing a fear conditioning and extinction paradigm found that individuals reporting higher anxiety in response to uncertainty had a generalized increase in AMY activation during CS+ and CS− presentations in early extinction, as well as higher vmPFC activity during late extinction [29]. A limited amount of work has thus far investigated EEG biomarkers in PTSD patients [30], including studies investigating whether there are abnormalities in EEG activity in different frequency bands. While many results have been inconsistent, some have found altered theta/alpha activity in PTSD patients, which correlated with symptom severity [30,31].…”

Section: Introductionmentioning

confidence: 99%

“…A limited amount of work has thus far investigated EEG biomarkers in PTSD patients [30], including studies investigating whether there are abnormalities in EEG activity in different frequency bands. While many results have been inconsistent, some have found altered theta/alpha activity in PTSD patients, which correlated with symptom severity [30,31]. Together, the available findings suggest that consistent markers may be associated with fear regulation, which is highly relevant for translating PTSD research.…”

Section: Introductionmentioning

confidence: 99%

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Activity-dependent signaling: influence on plasticity in circuits controlling fear-related behavior

Hill

Martinowich

2016

Current Opinion in Neurobiology

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Fear regulation is impaired in anxiety and trauma-related disorders. Patients experience heightened fear expression and reduced ability to extinguish fear memories. Because fear regulation is abnormal in these disorders and extinction recapitulates current treatment strategies, understanding the underlying mechanisms is vital for developing new treatments. This is critical because although extinction-based exposure therapy is a mainstay of treatment, relapse is common. We examine recent findings describing changes in network activity and functional connectivity within limbic circuits during fear regulation, and explore how activity-dependent signaling contributes to the neural activity patterns that control fear and anxiety. We review the role of the prototypical activity-dependent molecule, brain-derived neurotrophic factor (BDNF), whose signaling has been critically linked to regulation of fear behavior.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activity-dependent signaling: influence on plasticity in circuits controlling fear-related behavior

Hill

Martinowich

2016

Current Opinion in Neurobiology

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“…Thus far findings of alpha modulations in PTSD have focused on resting state measurements and have remained inconclusive 49, [52][53][54][55][56] . Taking these into consideration, while at rest, oscillatory alpha power in PTSD might vary depending on the trauma etiology of the patient group.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have directly investigated alpha power changes in PTSD and results remain inconclusive 49,52,53 . Differences in oscillatory alpha activity during resting state were found among PTSD groups with different trauma etiology.…”

mentioning

confidence: 99%

Aberrant brain response after auditory deviance in PTSD compared to trauma controls: An EEG study

Bangel

Buschbach

Smit

et al. 2017

Preprint

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Part of the symptomatology of post-traumatic stress disorder (PTSD) are alterations in arousal and reactivity which could be related to a maladaptive increase in the automated sensory change detection system of the brain. In the current EEG study we investigated whether the brain's response to a simple auditory sensory change was altered in patients with PTSD relative to trauma-exposed matched controls who did not develop the disorder. Thirteen male PTSD patients and trauma-exposed controls matched for age and educational level were presented regular auditory pure tones (1000 Hz, 200 ms duration), with 11% of the tones deviating in both duration (50 ms) and frequency (1200 Hz) while watching a silent movie. Relative to the controls, patients who had developed PTSD showed enhanced mismatch negativity (MMN), increased theta power (5-7 Hz), and stronger suppression of upper alpha activity (13-15 Hz) after deviant vs. standard tones. Behaviourally, the alpha suppression in PTSD correlated with decreased spatial working memory performance suggesting it might reflect enhanced stimulus-feature representations in auditory memory. These results taken together suggest that PTSD patients and trauma-exposed controls can be distinguished by enhanced involuntary attention to changes in sensory patterns.

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“…[1][2][3][4] It has been reported that EEG activity change is associated with psychiatric disorders. [5][6][7][8][9][10][11] Lee et al reported that the functional connectivity of beta frequency was decreased in patients with post-traumatic stress disorder (PTSD) compared to healthy controls, and beta connectivity was correlated with PTSD symptoms. 12 Changes in the beta band have been related to panic disorder as well.…”

mentioning

confidence: 99%

Increased beta power in the bereaved families of the Sewol ferry disaster: A paradoxical compensatory phenomenon? A two‐channel electroencephalography study

Jang

Shim

Lee

et al. 2017

Psychiatry Clin Neurosci

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This study suggests that increased beta power, reflecting the psychopathology in the bereaved families of the Sewol ferry disaster, may be a compensatory mechanism that follows complex trauma. Frontal beta power could be a potential marker indicating the severity of sleep disturbances. Our results suggest that sleep disturbance is an important symptom in family members of the Sewol ferry disaster's victims, which may be screened by EEG beta power.

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EEG correlates of the severity of posttraumatic stress symptoms: A systematic review of the dimensional PTSD literature

Cited by 78 publications

References 89 publications

Activity-dependent signaling: influence on plasticity in circuits controlling fear-related behavior

Activity-dependent signaling: influence on plasticity in circuits controlling fear-related behavior

Aberrant brain response after auditory deviance in PTSD compared to trauma controls: An EEG study

Increased beta power in the bereaved families of the Sewol ferry disaster: A paradoxical compensatory phenomenon? A two‐channel electroencephalography study

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