EEG-based spatio-temporal relation signatures for the diagnosis of depression and schizophrenia

Abstract

The diagnosis of psychiatric disorders is currently based on a clinical and psychiatric examination (intake). Ancillary tests are used minimally or only to exclude other disorders. Here, we demonstrate a novel mathematical approach based on the field of p-adic numbers and using electroencephalograms (EEGs) to identify and differentiate patients with schizophrenia and depression from healthy controls. This novel approach examines spatio-temporal relations of single EEG electrode signals and characterizes the topological structure of these relations in the individual patient. Our results indicate that the relational topological structures, characterized by either the personal universal dendrographic hologram (DH) signature (PUDHS) or personal block DH signature (PBDHS), form a unique range for each group of patients, with impressive correspondence to the clinical condition. This newly developed approach results in an individual patient signature calculated from the spatio-temporal relations of EEG electrodes signals and might help the clinician with a new objective tool for the diagnosis of a multitude of psychiatric disorders.

Rao-Fisher information geometry and dynamics of the event-universe views distributions

“…The role of the four parameters that stem from the shape complexity measure is intriguing and should be carefully studied further with possible application to other fields of physics, mathematics, biology, and medicine [ 32 , 33 ].…”

Relational information framework, causality, unification of quantum interpretations and return to realism through non-ergodicity

“…Dendrogramic Holographic Theory (DHT) is a singular postulate theory of relational information, conceived through a series of studies [1][2][3][4][5][6]. This theory represents a relational-event-observational approach to physics and the broader realm of natural science [7,8]. The foundational postulate underpinning and driving all theoretical implications is the adherence to Leibniz's Principle [9].…”