EEG Bands of Wakeful Rest, Slow-Wave and Rapid-Eye-Movement Sleep at Different Brain Areas in Rats

Evidence from population-based epidemiological studies, experimental sleep deprivation (SD) studies and interventional studies has provided important links between hypertension and sleep disorders (Bruno et al., 2013; Gangwisch, 2014). Hypertension has been shown to be associated with a short sleep duration in both cross-sectional and longitudinal epidemiological studies (Gangwisch, 2014). SD or insufficient sleep can raise blood pressure and lead to structural adaptations that can increase the risk for hypertension (Javaheri,

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“…Beta waves occur during a heightened state of awareness (Fransen, Dimitriadis, van Ede, & Maris, 2016;Jing et al, 2016).…”

Section: Electroencephalographic Spectrum Analysismentioning

confidence: 99%

Serotonergic system may be involved in alterations of sleep homeostasis in spontaneously hypertensive rats

Cui

Huang

Cui

et al. 2019

Journal of Sleep Research

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“…Although there are several studies that have analyzed the iEEG during W and sleep, most of them have not evaluated the whole spectrum of frequencies (from delta to HFO), the differences between brain areas, lateralization and the phases of the circadian cycle. Additionally, the ones that did, have focused in just one of these parameters without evaluating the effect of all of them [ 20 , 21 , 23 , 24 , 25 ]. Therefore, a detailed and systematic evaluation, that evaluates the impact of behavioral states, cortical area, lateralization and light/dark phases of power and coherence during behavioral states is still pending.…”

Section: Introductionmentioning

confidence: 99%

Power and Coherence in the EEG of the Rat: Impact of Behavioral States, Cortical Area, Lateralization and Light/Dark Phases

et al. 2020

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The sleep-wake cycle is constituted by three behavioral states: wakefulness (W), non-REM (NREM) and REM sleep. These states are associated with drastic changes in cognitive capacities, mostly determined by the function of the thalamo-cortical system, whose activity can be examined by means of intra-cranial electroencephalogram (iEEG). With the purpose to study in depth the basal activity of the iEEG in adult rats, we analyzed the spectral power and coherence of the iEEG during W and sleep in the paleocortex (olfactory bulb), and in neocortical areas. We also analyzed the laterality of the signals, as well as the influence of the light and dark phases. We found that the iEEG power and coherence of the whole spectrum were largely affected by behavioral states and highly dependent on the cortical areas recorded. We also determined that there are night/day differences in power and coherence during sleep, but not in W. Finally, we observed that, during REM sleep, intra-hemispheric coherence differs between right and left hemispheres. We conclude that the iEEG dynamics are highly dependent on the cortical area and behavioral states. Moreover, there are light/dark phases disparities in the iEEG during sleep, and intra-hemispheric connectivity differs between both hemispheres during REM sleep.

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“…Of translational value, rodent EEG measures correspond to, with a number of caveats, human EEG measures. For example, the power spectra at the surface of the cortex for both rodents and humans follow a similar frequency power profile [ 21 ]. Collectively, synchronized EEG activity reflects the sum of spatially distributed neuronal oscillations that serve ongoing sensory processing, affective modulation, and higher-order thought processes of the brain.…”

Section: Introductionmentioning

confidence: 99%

Time and frequency dependent changes in resting state EEG functional connectivity following lipopolysaccharide challenge in rats

et al. 2018

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Research has shown that inflammatory processes affect brain function and behavior through several neuroimmune pathways. However, high order brain functions affected by inflammation largely remain to be defined. Resting state functional connectivity of synchronized oscillatory activity is a valid approach to understand network processing and high order brain function under different experimental conditions. In the present study multi-electrode EEG recording in awake, freely moving rats was used to study resting state connectivity after administration of lipopolysaccharides (LPS). Male Wistar rats were implanted with 10 cortical surface electrodes and administered with LPS (2 mg/kg) and monitored for symptoms of sickness at 3, 6 and 24 h. Resting state connectivity and power were computed at baseline, 6 and 24 h. Three prominent connectivity bands were identified using a method resistant to spurious correlation: alpha (5–15 Hz), beta-gamma (20–80 Hz), and high frequency oscillation (150–200 Hz). The most prominent connectivity band, alpha, was strongly reduced 6 h after LPS administration, and returned to baseline at 24 h. Beta-gamma connectivity was also reduced at 6 h and remained reduced at 24 h. Interestingly, high frequency oscillation connectivity remained unchanged at 6 h and was impaired 24 h after LPS challenge. Expected elevations in delta and theta power were observed at 6 h after LPS administration, when behavioral symptoms of sickness were maximal. Notably, gamma and high frequency power were reduced 6 h after LPS and returned to baseline by 24 h, when the effects on connectivity were more evident. Finally, increases in cross-frequency coupling elicited by LPS were detected at 6 h for theta-gamma and at 24 h for theta-high frequency oscillations. These studies show that LPS challenge profoundly affects EEG connectivity across all identified bands in a time-dependent manner indicating that inflammatory processes disrupt both bottom-up and top-down communication across the cortex during the peak and resolution of inflammation.

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EEG Bands of Wakeful Rest, Slow-Wave and Rapid-Eye-Movement Sleep at Different Brain Areas in Rats

Cited by 25 publications

References 62 publications

Serotonergic system may be involved in alterations of sleep homeostasis in spontaneously hypertensive rats

Serotonergic system may be involved in alterations of sleep homeostasis in spontaneously hypertensive rats

Power and Coherence in the EEG of the Rat: Impact of Behavioral States, Cortical Area, Lateralization and Light/Dark Phases

Time and frequency dependent changes in resting state EEG functional connectivity following lipopolysaccharide challenge in rats

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