Edulcorantes No Nutritivos (No Calóricos)

Torres, Diana; Muñoz, Tomás García; Bancalari, Aldo; Manríquez, C

doi:10.4067/s0370-41062018005000807

Cited by 6 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibiotics have attracted much attention as one of the most important factors that causes microbial dysbiosis during infancy and are linked to a higher risk of diseases with immune involvement in later life, including infectious diseases (10,(41)(42)(43)(44). In case control retrospective studies, prolonged exposure to antibiotic therapy was found to be associated with an increased risk of necrotizing enterocolitis, late-onset sepsis, or death among very low birth weight infants (41,(45)(46)(47). By analyzing the stool microbiota and metabolites of preterm infants with seven days of empirical antibiotic treatment, Zhu et al showed a significant reduction in bacterial diversity and enrichment of pathogens, such as Streptococcus and Pseudomonas (48).…”

Section: Impact On Host Defense Against Infectionmentioning

confidence: 99%

The Dark Side of Antibiotics: Adverse Effects on the Infant Immune Defense Against Infection

Shekhar

Petersen

2020

Front. Pediatr.

View full text Add to dashboard Cite

Although antibiotics confer significant health benefits in treating or preventing bacterial infections, an accumulating wealth of evidence illustrates their detrimental effect on host-microbiota homeostasis, posing a serious menace to the global public health. In recent years, it is becoming evident that infants, who are subjected to frequent antibiotic exposures due to their vulnerability to infection, reflect increased susceptibility to a wide spectrum of diseases, including infection, in later life. Antibiotics induce perturbations of the microbiota or dysbiosis, which in turn alters the host immune responses against pathogens. In comparison with adults, antibiotic treatments in infants have disproportionate consequences because the infant microbiota represents an evolving system that is unstable and immature until 2-3 years of age. However, relatively less knowledge is available on how antibiotics affect the infant microbiota and immunity. In this review article, we focus on how antibiotic treatment regimens influence the infant innate and adaptive immunity to pathogens in humans and animal models, and make the host susceptible to infections in later life. There is a critical need to better understand the effect of antibiotics on infant immune function, which may have implications for developing effective prophylactics and therapeutics against diseases in infants and adults.

show abstract

Section: Impact On Host Defense Against Infectionmentioning

confidence: 99%

The Dark Side of Antibiotics: Adverse Effects on the Infant Immune Defense Against Infection

Shekhar

Petersen

2020

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

Melatonin Alleviates Neonatal Necrotizing Enterocolitis by Repressing the Activation of the NLRP3 Inflammasome

Xiong

Bao

et al. 2022

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Objective. Necrotizing enterocolitis (NEC) is one of the commonest gastrointestinal critical diseases in newborns. Several researches have proven the efficacy of melatonin (MEL) on NEC, but the latent mechanisms were ambiguous. We designed the current research to evaluate the function and mechanism of MEL on NEC in a neonatal mouse model. Methods. The newborn mice were subjected to formula milk containing LPS and hypoxia to establish a NEC model and also intraperitoneally injected with MEL. During the experiment, all mice were closely monitored and weighed. The effect of MEL on the histopathological injury of the terminal ileum tissues, inflammation, and oxidative stress of serum in NEC mice was examined by hematoxylin-eosin (H&E) staining and ELISA. The effect of MEL on the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome was assessed via quantitative real-time PCR and Western blot. Results. MEL intensified the survival rate and body weight in NEC mice. The H&E staining illustrated that MEL improved the histopathological injury in NEC mice. Moreover, MEL repressed the IL-1β, TNF-α, and MDA levels of serum and enhanced the SOD and GSH-Px levels of serum in NEC mice. We also discovered that MEL attenuated the mRNA and protein levels of NLRP3, Toll-like Receptor 4 (TLR4), NF-κB, and caspase-1 of the terminal ileum tissues in NEC mice. Conclusion. Our research illuminated that MEL attenuated the severity of NEC via weakening the activation of the NLRP3 inflammasome.

show abstract

Research Progress on Rational Use of Antibiotics in Neonatal Early-Onset Septicemia

陈¹

2022

ACM

View full text Add to dashboard Cite

Edulcorantes No Nutritivos (No Calóricos)

Cited by 6 publications

References 22 publications

The Dark Side of Antibiotics: Adverse Effects on the Infant Immune Defense Against Infection

The Dark Side of Antibiotics: Adverse Effects on the Infant Immune Defense Against Infection

Melatonin Alleviates Neonatal Necrotizing Enterocolitis by Repressing the Activation of the NLRP3 Inflammasome

Research Progress on Rational Use of Antibiotics in Neonatal Early-Onset Septicemia

Contact Info

Product

Resources

About