Educational performance and conduct problem trajectories from childhood to adolescence: Observational and genetic associations in a Brazilian birth cohort

Abstract

Background Educational difficulties are an important potential influence on both the onset and course of children's conduct problems. This study evaluated the association between school failure and children's conduct problems in Brazil, a context with high rates of both conditions, using both observational and genetic approaches. Methods Prospective, population‐based, birth cohort study in Pelotas city, Brazil. Parents reported on conduct problems four times between ages 4–15 years, and group‐based trajectory analysis was used to classify 3469 children into trajectories of childhood‐limited, early‐onset persistent, adolescence‐onset, or low conduct problems. School failure was measured as having repeated a school grade up to age 11, and a polygenic risk score (PRS) predicting educational attainment was calculated. Multinomial adjusted regression models were used to estimate the association between school failure (observational measure and the PRS) and conduct problem trajectories. To consider possible variation in effects of school failure by social context, interactions were tested with family income and school environment (using both observational and PRS methods). Results Children repeating a school grade had increased odds of being on to childhood‐limited (OR: 1.57; 95% CI 1.21; 2.03), adolescence‐onset (OR: 1.96; 95% CI 1.39; 2.75), or early‐onset persistent trajectory (OR: 2.99; 95% CI 1.85; 4.83), compared to the low conduct problem trajectory. School failure also predicted increased risk for early‐onset persistent problems versus the childhood‐limited problems (OR: 1.91; 95% CI 1.17; 3.09). Using a genetic PRS approach, similar findings were observed. Associations varied according to the school environment: school failure had larger effects on children in better school environments. Conclusion School performance, whether measured in terms of repeating school grades or genetic susceptibility, was consistently associated with trajectories of child conduct problems into mid‐adolescence. We also found a larger association for children in better school environments.

Prevalence of and Factors Associated With High Blood Pressure at 15 Years of Age: A Birth Cohort Study

“…Imputation of remaining nongenotyped variants and quality control filtering were done as described elsewhere. 29 The PRSs for SBP and DBP were calculated as the weighted sum of risk alleles for SBP and DBP, according to the largest genome‐wide association study to date. 30 The scoring files deposited in the PRS catalog were used to construct the PRS (PRS Catalog Publication ID PGP000283).…”