Educational Challenges Facing Basic Science Faculties

Harrold, Marc W.

doi:10.5688/aj680115

Cited by 11 publications

(11 citation statements)

References 3 publications

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“…The lack of student motivation is always an issue with science courses taught in a health sciences professional program, especially when instructors do not try to make their courses relevant for their students. 47,48 Instructor enthusiasm has been identified as an external catalyst for the intrinsic motivational energy that may be lying dormant within students. [9][10][11][12] It is even more critical when teaching college students as many of them are used to a system of external incentives (eg, grades).…”

Section: Discussionmentioning

confidence: 99%

A Three-Year Study of the Impact of Instructor Attitude, Enthusiasm, and Teaching Style on Student Learning in a Medicinal Chemistry Course

Alsharif

Yuan

2014

American Journal of Pharmaceutical Education

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Objective. To determine the effect of instructor attitude, enthusiasm, and teaching style on learning for distance and campus pharmacy students. Methods. Over a 3-year period, distance and campus students enrolled in the spring semester of a medicinal chemistry course were asked to complete a survey instrument with questions related to instructor attitude, enthusiasm, and teaching style, as well as items to measure student intrinsic motivation and vitality. Results. More positive responses were observed among distance students and older students. Gender did not impact student perspectives on 25 of the 26 survey questions. Student-related items were significantly correlated with instructor-related items. Also, student-related items and second-year cumulative grade point average were predictive of students' final course grades. Instructor enthusiasm demonstrated the highest correlation with student intrinsic motivation and vitality. Conclusion. While this study addresses the importance of content mastery and instructional methodologies, it focuses on issues related to instructor attitude, instructor enthusiasm, and teaching style, which all play a critical role in the learning process. Thus, instructors have a responsibility to evaluate, reevaluate, and analyze the above factors to address any related issues that impact the learning process, including their influence on professional students' intrinsic motivation and vitality, and ability to meet educational outcomes.

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Section: Discussionmentioning

confidence: 99%

A Three-Year Study of the Impact of Instructor Attitude, Enthusiasm, and Teaching Style on Student Learning in a Medicinal Chemistry Course

Alsharif

Yuan

2014

American Journal of Pharmaceutical Education

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“…1 Instructors may be accustomed to teaching using traditional lecture-based instruction that focuses on content delivery and places less emphasis on Throughout, the manuscript we use the term foundational science instead of basic science to discern the relationship between sciences underlying pharmacy practice versus the sciences underlying other future applications (eg, benchtop research).…”

Section: Introductionmentioning

confidence: 99%

Practical Tips for Integrating Clinical Relevance into Foundational Science Courses

Greene

Fuller

Persky

2018

American Journal of Pharmaceutical Education

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The integration of foundational science and clinical science education is a hallmark of health profession education reform, and an increasing number of pharmacy schools are implementing integrated curricula in professional pharmacy programs. Although the foundational sciences serve as an essential framework for understanding clinical knowledge, instructors may face challenges when integrating clinical science into foundational science courses. Here we present practical learner-centered teaching tips to address these challenges.

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“…In fact, a few research groups have obtained experimental evidence that links the polypharmacology of drug candidates to the ability of these compounds to adopt multiple low-energy conformations. [17][18][19] Examples in which polypharmacology has been associated with ligand conformational change support the potential utility of commonly employed strategies to decrease polypharmacology. In particular, in an effort to decrease promiscuity, chemists often attempt to limit the number of accessible conformations of a lead molecule.…”

Section: Introductionmentioning

confidence: 99%

Promiscuity and the Conformational Rearrangement of Drug‐Like Molecules: Insight from the Protein Data Bank

Lee

Sweeney

2014

ChemMedChem

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Selectivity is a central aspect of lead optimization in the drug discovery process. Medicinal chemists often try to decrease molecular flexibility to improve selectivity, given the common belief that the two are interdependent. To investigate the relationship between polypharmacology and conformational flexibility, we mined the Protein Data Bank and constructed a dataset of pharmaceutically relevant ligands that crystallized in more than one protein target while binding to each co-crystallized receptor with similar in vitro affinities. After analyzing the molecular conformations of these 100 ligands, we found that 59 ligands bound to different protein targets without significantly changing conformation, suggesting that there is no distinct correlation between conformational flexibility and polypharmacology within our dataset. Ligands crystallized in similar proteins and highly ligand-efficient compounds with five or fewer rotatable bonds were less likely to adjust conformation when binding.

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Educational Challenges Facing Basic Science Faculties

Cited by 11 publications

References 3 publications

A Three-Year Study of the Impact of Instructor Attitude, Enthusiasm, and Teaching Style on Student Learning in a Medicinal Chemistry Course

A Three-Year Study of the Impact of Instructor Attitude, Enthusiasm, and Teaching Style on Student Learning in a Medicinal Chemistry Course

Practical Tips for Integrating Clinical Relevance into Foundational Science Courses

Promiscuity and the Conformational Rearrangement of Drug‐Like Molecules: Insight from the Protein Data Bank

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