Educational attainment and response to HAART during initial therapy for HIV-1 infection

Marc, Linda G.; Testa, Marcia A.; Walker, Alexander M.; Robbins, Gregory K.; Shafer, Robert W.; Anderson, Norman B.; Berkman, Lisa F.

doi:10.1016/j.jpsychores.2007.04.009

Cited by 17 publications

(15 citation statements)

References 101 publications

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“…In both Switzerland and the United States of America, people with lower educational attainment or socioeconomic status have been found to be relatively less likely to initiate cART. 21,22 However, among treated individuals, data on the association between educational attainment and the progression of HIV disease are conflicting, 21,23 probably because context-specific factors (e.g. adherence support) may mitigate the health-related sequelae of social deprivation.…”

Section: Researchmentioning

confidence: 99%

Impact of expanded access to combination antiretroviral therapy in pregnancy: results from a cohort study in Ukraine

Bailey

Townsend²,

Semenenko³

et al. 2013

Bull. World Health Organ.

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Section: Researchmentioning

confidence: 99%

Impact of expanded access to combination antiretroviral therapy in pregnancy: results from a cohort study in Ukraine

Bailey

Townsend²,

Semenenko³

et al. 2013

Bull. World Health Organ.

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“…Mental health personnel (in-house and contractors) also imparted that factors known to predict mental health service seeking 29 , and predict uptake and adherence to ARV-PEP 30–34 , were not systematically collected at HUEH during intake. These factors include, but are not limited to, background characteristics of the victim (e.g., education, socioeconomic status, marital status, history of sexual violence, history of childhood sexual abuse), characteristics of the assault (e.g., perpetrator type – partner, relative, acquaintance or stranger), severity of violence, drug/alcohol exposure during the assault, and prior traumatic events experienced by the victim.…”

Section: Resultsmentioning

confidence: 99%

Uptake to HIV Post‐Exposure Prophylaxis in Haiti: Opportunities to Align Sexual Violence, HIV PEP and Mental Health

Marc

Honoré

Néjuste

et al. 2012

American J Rep Immunol

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Problem Sexual violence is a public health problem in Haiti, potentially augmenting HIV transmission. Reports from L’Hôpital de l’Université d’État d’Haiti (HUEH) suggest severe underutilization of antiretroviral post-exposure prophylaxis (ARV-PEP) amongst rape survivors. Method of Study Cross-sectional design using mixed methods. Informational-interviews were conducted with HUEH personnel to learn about post-rape service offerings. HUEH surveillance data was used to estimate the sexual assault reporting rate/100,000; and to examine the proportion of survivors receiving ARV-PEP within 72 hours, stratified by age (<18 years, ≥18 years). Results Informational-interviews revealed that survivors were navigated through two hospital algorithms to receive post-rape care, however, less than 5% of victims sought mental health services. Surveillance data show that 2,193 sexual assault survivors (adult and pediatric) reported a rape to HUEH personnel between 2004 through first quarter 2010. Annual estimates suggest a 2-fold increase comparing cases in 2004 versus 2009. Between 2008–2009, uptake to ARV-PEP within 72-hours was lower for pediatric (38.4%; N=131/341) compared to adult survivors (60.1%; N=83/138) (χ2 = 18.8, p < 0.001). Conclusions The prioritization of funding and comprehensive interventions that align sexual violence, HIV and mental health are crucial to support the timely uptake to ARV-PEP.

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“…For 153 patients, education data was unavailable and had to be imputed by statistical analysis. One cannot therefore entirely rule out the importance of the education level variable in the adversity index, particularly since previous studies have found associations between lower education level and cART failure [15,20,46]. The authors considered the development of a multiitem additive scale as an alternative approach to quantify the impact of demographic and psychosocial variables within different domains 1) demographic factors 2), economic hardship, 3) familial stress, 4) substance abuse, 5) other mental health problems on HIV care.…”

Section: Discussionmentioning

confidence: 99%

The Detrimental Effect of Adversity on HIV Outcomes in the Era of Combined Anti-Retroviral Therapy

Cancedda¹,

Eddens²,

Adebona³

et al. 2012

WJA

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Socially disadvantaged individuals with HIV experience unacceptably high rates of AIDS and death. The authors developed an adversity index to quantify the impact of demographic and psychosocial factors on HIV care. This retrospective cohort study included 431 participants with HIV on combined antiretroviral therapy between 2000 and 2005. Poor outcome was defined as progression to AIDS, death, virologic failure, or CD4 < 200 cells/µl at six months. The index utilized eight demographic and psychosocial variables independently associated with poor outcome. Exposure to higher numbers of variables in the adversity index significantly increased the rates of poor outcome from 14% (exposure to no variables) to 100% (exposure to seven variables). The odds of poor outcome decreased but remained significant after adjusting for adherence-defining variables, indicating a possible mediating effect of poor adherence. Durably effective therapeutic strategies must include addressing adverse demographic and psychosocial factors affecting people living with HIV.

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Educational attainment and response to HAART during initial therapy for HIV-1 infection

Cited by 17 publications

References 101 publications

Impact of expanded access to combination antiretroviral therapy in pregnancy: results from a cohort study in Ukraine

Impact of expanded access to combination antiretroviral therapy in pregnancy: results from a cohort study in Ukraine

Uptake to HIV Post‐Exposure Prophylaxis in Haiti: Opportunities to Align Sexual Violence, HIV PEP and Mental Health

The Detrimental Effect of Adversity on HIV Outcomes in the Era of Combined Anti-Retroviral Therapy

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