Background: In 2019, coronavirus disease pandemic (COVID-19) influences the quality of life of health personnel who are on the front lines in dealing with COVID-19 patients. Aim and objectives: The Aim of the study was to assess the quality of life of medical doctor and public health specialist who worked during COVID19, Saudi Arabia, and Riyadh 2022 and to analysis the different risk factors affect the quality of life of medical doctors and public health specialist who worked during COVID19, Saudi Arabia, and Riyadh 2022. Subjects and methods: This was an analytic cross sectional which was done at Kingdome of Saudi Arabia, Riyadh,for medical doctors and public health specialist. Results: There was statistically significant difference in psychological domain between participants with physical or psychological disorders and those without, as participants with no physical or psychological disorders had higher psychological domain (mean = 64.55 ± 16.46) than participants with physical or psychological disorders (mean = 49.89± 16.86), p-value<0.001. Conclusion: The present study revealed health care workers’ quality of life during and after the outbreak of the COVID-19 pandemic. Factors such as marital status, physical and psychological disorders, place of work and specialty were significantly associated with decrease the quality of life.