Education, Occupation, and Alzheimer's Disease

Devitt, Neal

doi:10.1001/jama.1994.03520180029015

Cited by 1 publication

(1 citation statement)

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“…It is possible that the connection between lower socioeconomic status (such as suggested by lower education, occupation, or less engaged lifestyle) and dementia is through exposure to more environmental insults (such as pollutants and industrial and nonindustrial toxins), habits such as heavy drinking, or other factors associated with low income and poverty (such as malnutrition, healthcare quality and access, and higher rates of cerebrovascular disease) that may result in incipient neurologic damage and lower the threshold for clinical manifestation of dementia [89][90][91]. According to this model, higher cognitive capacities in high-education occupation subjects may be mediated through avoidance of potentially neurotoxic factors and behaviors.…”

Section: Possible Mechanismsmentioning

confidence: 99%

Cognitive reserve: Implications for diagnosis and prevention of Alzheimer’s disease

Scarmeas

Stern

2004

Curr Neurol Neurosci Rep

207

132

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Epidemiologic evidence suggests that higher occupational attainment and education, as well as increased participation in intellectual, social, and physical aspects of daily life, are associated with slower cognitive decline in healthy elderly and may reduce the risk of incident Alzheimer's disease (AD). There is also evidence from structural and functional imaging studies that patients with such life experiences can tolerate more AD pathology before showing signs of clinical dementia. It has been hypothesized that such aspects of life experience may result in functionally more efficient cognitive networks and, therefore, provide a cognitive reserve that delays the onset of clinical manifestations of dementia. In this article, we review some of the relevant literature of the noted associations between markers of cognitive reserve and AD and discuss the possible mechanisms that may explain these associations.

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Section: Possible Mechanismsmentioning

confidence: 99%