As a direct benefit of the Health Care Reform Act (2010), concerted effort has been deployed to define and characterize the process
by which the best available evidence for diagnosis or treatment intervention prognosis can be obtained. The science of research
synthesis in health care has established the systematic research protocol by which randomized clinical trials and other clinical
studies must be reviewed and compared for the level and quality of the evidence presented, as well as the consensus of the best
available evidence synthesized and shared. This process of systematic review yields a reliable and valid approach in comparing
different interventions and strategies to prevent, diagnose, treat and monitor health conditions in terms of efficacy, and or of
effectiveness. The resulting bioinformation outcome of comparative effectiveness and efficacy research review of the available
clinical data is expressed as a consensus of the best available evidence, which finds its way in evidence-based clinical practice
guidelines, standards of care and eventually, in policies: hence, the acronym CEERAP (comparative effectiveness and efficacy
review and policy). The methodological and the procedural criteria that determine and regulate the public reporting dissemination
of this sort of bioinformation, and the extent of benefit to the patient's health literacy, which have remained a bit more elusive to
this date, are investigated and discussed in this paper.