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AUTHOR(S)Christine C. Johnson, Ph.D.
FUNDING NUMBERS
DAMD17-96-1-6246
PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)Henrv Ford Health Svstem Detroit, Michigan 48202 E-Mail: cjohnsol@hflis.org The objective of our research program was to develop a research infrastructure for studies defining molecular markers and their interaction with other factors as risk indicators for development of breast cancer among women with benign breast disease (BBD). We estimated the incidence of breast cancer development in African American and Caucasian women with biopsy-proven BBD and collected and archived in a specimen bank samples of benign breast disease lesions and breast cancer from women in this cohort. We also developed a culturally sensitive questionnaire for collecting breast cancer risk factor information. We constructed a cohort of women with BßD between 1981-1994 who were followed from 5-15 years and yielded 218 women who developed invasive breast cancer. This work built the foundation, in terms of a cohort, a specimen bank and a survey instrument for the conduct of molecular epidemiologic studies of breast cancer in a multi-ethnic population.
PERFORMING ORGANIZATION REPORT NUMBER
SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES)U
SUBJECT TERMSBenign breast disease and breast cancer Breast cancer in a mult-ethnic population Where copyrighted material is quoted, permission has been obtained to use such material.Where material from documents designated for limited distribution is quoted, permission has been obtained to use the material.Citations of commercial organizations and trade names in this report do not constitute an official Department of Army endorsement or approval of the products or services of these organizations.In conducting research using animals, the investigator(s) adhered to the "Guide for the Care and Use of Laboratory Animals," prepared by the Committee on Care and use of Laboratory Animals of the Institute of Laboratory Resources, national Research Council (NIH Publication No. 86-23, Revised 1985).For the protection of human subjects, the investigator(s) adhered to policies of applicable Federal Law 45 CFR 46.In conducting research utilizing recombinant DNA technology, the investigator(s) adhered to current guidelines promulgated by the National Institutes of Health.In the conduct of research utilizing recombinant DNA, the investigator(s) adhered to the NIH Guidelines for Research Involving Recombinant DNA...