Edrophonium-induced asystole following neuromuscular blockade antagonism in a dog: a case report

Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep

“…1982) which demonstrated atropine’s positive chronotropic effects in humans. Similar responses were reported in dogs: the propensity for edrophonium to produce cardiac arrest (Clutton & Petersen‐Jones 1991) is prevented by atropine.…”

“…Increased ACh at muscarinic receptors on parasympathetic nervous effector organs result in vagomimetic signs. However, bradycardia and bradyarrhythmias are the most important complication; severe, occasionally fatal arrhythmias have occurred with edrophonium in humans (Youngberg 1979) and dogs (Clutton & Petersen‐Jones 1991). Bradyarrhythmias are prevented by administering antimuscarinic drugs, e.g.…”

Reversal of neuromuscular block in companion animals

“…Some dogs develop transient signs of proctitis (tenesmus with bloody diarrhea). In dogs a second-degree atrioventricular blockade (Clutton 1994) and a case report of an asystole (Clutton & Peterson-Jones 1991) have been reported after edrophonium. It has also been demonstrated that neostigmine but not edrophonium produced broncho-constriction in rat tracheal slices (Shibata et al 1996).…”