This study focuses on the relationship between erosion and land use and land cover changes (LULCC) in the Ergene Basin. RUSLE (3D) method, which is based on geographical information systems (GIS) and remote sensing (RS) techniques, was used in the study. In accordance with the research aim, Landsat satellite images were used to analyze LULCC from 1987 to 2015. Based on this dataset, two different C (land cover and management) factor maps were produced. LULCC in years manifest themselves in also C factor and thus obviously affect soil erosion indirectly. In this regard, the effects of anthropogenic LULCC on erosion were investigated and determined. It was found out that as LULCC have occurred in the Ergene Basin in the last 28 years, average annual soil loss has decreased (-1.67 t ha¯¹ per year) as a result of the growth of residential areas. However, this, which seems positive at first glance, is because the effects of severe erosion that has increased in the area have not manifested themselves yet. It should be noted that uncontrolled growth of residential areas will give rise to some basic agricultural problems. The results of this study confirm the existence of a strong and significant relationship between LULCC and erosion. Some measures should be taken urgently so that erosion risk in the Ergene Basin is reduced to optimum level in the near future.