Editorial: Zebrafish Epigenetics

Cavalieri, Vincenzo; Kathrein, Katie L.

doi:10.3389/fcell.2022.977398

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Histone O- Glcnacylation1

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2023

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“…This study demonstrated that epigenetic processes/machineries are not fully conserved between vertebrates, pinpointing the existence of species-dependent regulatory mechanisms and limiting the use of particular animal models, depending on the scientific hypothesis ( e.g ., zebrafish are commonly used as a model for epigenetic studies but lack the H2A S40 isoform; Fig. 3 , Table 1) [ 24 ]…”

Section: Histone O- Glcnacylationmentioning

confidence: 99%

O-GlcNAcylation: the sweet side of epigenetics

Dupas,

Lauzier,

McGraw

2023

Epigenetics & Chromatin

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Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function without altering the DNA sequence. Histones can also undergo post-translational O-GlcNAcylation, a rather understudied modification that plays critical roles in almost all biological processes and is added and removed by O-linked N-acetylglucosamine transferase and O-GlcNAcase, respectively. This review provides a current overview of our knowledge of how O-GlcNAcylation impacts the histone code both directly and by regulating other chromatin modifying enzymes. This highlights the pivotal emerging role of O-GlcNAcylation as an essential epigenetic marker.

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Section: Histone O- Glcnacylationmentioning

confidence: 99%