Editorial

Witte, MH; Bernas, M.

doi:10.2458/lymph.4650

Cited by 6 publications

(5 citation statements)

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“…The International Society of Lymphology (ISL), the National Lymphedema Network (NLN), and most experts recommend the use of compressions, especially during vigorous physical activity, for BCRL in clinical settings [16,33,40,41]. There are studies in the literature reporting that participation in low-to-moderate-intensity aerobic and resistive exercise programs without compression sleeves do not acutely (immediately after exercise or at 24 h) precipitate or exacerbate lymphedema [34,[42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Acute Effects of Remedial Exercises with and without Compression on Breast-Cancer-Related Lymphedema

Gülören,

Doğan,

Özgül

et al. 2023

Healthcare

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Remedial exercises are an important part of the treatment for lymphedema, but there is little evidence to support the acute effects of remedial exercises with or without compression. The aim of this study was to investigate whether and how daily (performed within 24 h) remedial exercises with and without compression bandaging acutely affect the severity of lymphedema and its symptoms in breast-cancer-related lymphedema (BCRL). In total, 34 patients with BCRL completed three sets of remedial exercises (within 24 h) with and without compression bandaging in a randomized order separated by a 3-day wash-out period. The severity of lymphedema and extracellular water ratio were assessed before and 24 h post exercise by using bilateral circumferential measurements and bioimpedance spectroscopy (in L-dex score), respectively, and the severity of self-reported symptoms (swelling, heaviness, and tightness) was assessed using a visual analogue scale. While there was no difference in all outcomes at 24 h post exercise without compression (p > 0.05), all outcomes decreased significantly compared to baseline at 24 h after the exercise with compression (p < 0.001). The remedial exercises performed in the absence of compression within 24 h do not acutely increase the lymphedema and symptoms in BCRL. These are important preliminary findings, which can be used to inform future prospective evaluation of the long-term effects of remedial exercise performed without compression.

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Section: Discussionmentioning

confidence: 99%

Acute Effects of Remedial Exercises with and without Compression on Breast-Cancer-Related Lymphedema

Gülören,

Doğan,

Özgül

et al. 2023

Healthcare

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“…The International Society of Lymphology [ 13 ] scale is utilized for staging lymphedema, and each patient is assessed based on the following stages [ 14 ]: Stage 0: This is a subclinical condition in which there is no apparent swelling despite impairment of lymphatic transport. Stage 1: This is an early stage of the disease with visible accumulation of protein-rich tissue fluid.…”

Section: Methodsmentioning

confidence: 99%

Fatigue and sleep quality improvement through complete decongestive therapy in postmastectomy lymphedema: An investigative analysis

Kavak,

Kavak

2024

Support Care Cancer

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Objective To evaluate the effects of complete decongestive therapy (CDT) on cancer-related fatigue, sleep quality, and lymphedema-specific quality of life using validated and reliable questionnaires in cancer patients being commendable. Material and methods This prospective study includes 94 patients who had postmastectomy lymphedema syndrome. The demographic characteristics of the patients were recorded. The participants’ stages of lymphedema (The International Society of Lymphology), Hirai Cancer Fatigue Scale (HCFS) score, Pittsburgh Sleep Quality Index (PSQI) Global score, lymphedema-specific quality of life questionnaire (LYMQOL-ARM) score, and Global health status were recorded before and after CDT. Results The mean age of the patients was 58.49 ± 10.96 years. Strong correlations were found between the severity of edema and global health status. There was a significant positive relationship between the HCFS score, PSQI Global score, LYMQOL-ARM score, and CDT. After decongestive physiotherapy, the majority of the lymphedema stages were downstaging (p < 0.05), respectively. There was also a trend toward improvement in general well-being (p < 0.05). Conclusion Cancer-related fatigue and sleep disturbance can persist for years after surgery in women with breast cancer. This can negatively affect the patient physically, socially and cognitively. Our study, which is the first study to investigate the HCFS score in postmastectomy patients and the relationship between PSQI Global score and CDT. The findings identify the risk factors that affect these outcomes in women with lymphedema and can provide valuable insights for targeted interventions and improved patient care.

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“…While PU.1 itself is not located on chromosome 21, the altered genomic context in DS may indirectly affect PU.1 expression through chromatin remodeling or changes in transcriptional regulatory networks [48]. DS-associated alterations in chromatin structure or epigenetic marks may impact the expression of genes involved in regulating PU.1 expression [49]. For example, changes in DNA methylation patterns or histone modifications may affect PU.1 transcriptional activity.…”

Section: Down Syndrome Based Mutations (Gata1 Crlf2 Jak2 Ras) In All ...mentioning

confidence: 99%

Leukemogenesis in Acute Lymphoblastic Leukemia through the Lens of Developmental Dynamics of Lymphoid Progenitor Cells: a systematic review

Shafi,

Rajpar,

Kanwal

et al. 2024

Preprint

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ObjectiveThe objective of this study is to investigate how lymphoid progenitor mechanisms contribute to the leukemogenesis in Acute Lymphoblastic Leukemia.BackgroundAcute Lymphoblastic Leukemia (ALL), the leading childhood cancer, remains challenging despite treatment advances. ALL originates from aberrant clonal expansion of immature lymphoid progenitor cells (LPCs) due to genetic abnormalities. This study looks into LPC genetic dysregulations, aiming to identify therapeutic targets and enhance prognostic stratification. Understanding ALL pathogenesis not only improves outcomes but also informs broader cancer research, offering potential insights for hematologic malignancies and oncogenesis, promising advancements in clinical practice.MethodsDatabases, including PubMed, MEDLINE, Google Scholar, and open access/subscription-based journals were searched for published articles without any date restrictions, to investigate leukemogenesis in acute lymphoblastic leukemia and the impact of down syndrome through the developmental regulators of lymphoid progenitor cells. Based on the criteria mentioned in the methods section, studies were systematically reviewed to investigate ALL leukemogenesis. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).ResultsAcute Lymphoblastic Leukemia (ALL) development is marked by dysregulations in key factors governing Lymphoid Progenitor Cells (LPCs) proliferation and differentiation. Dysregulations include upregulation of transcription factors Ikaros and PU.1, along with heightened expression of surface markers CD34 and CD38. Increased levels of signaling molecules IL-7, SCF, and FLT3 Ligand drive LPC proliferation, while alterations in epigenetic modifiers DNMTs, HDACs, and HATs further contribute to uncontrolled cell division. Dysregulated transcription factors Ikaros, PU.1, E2A (TCF3), EBF1, and Notch1 disrupt LPC differentiation pathways, alongside aberrant expression of surface markers CD10, CD7, and CD45RA. Dysregulated signaling through IL-7 and the Notch pathway, along with epigenetic modifications mediated by DNMTs, HDACs, and HATs, collectively create a conducive landscape for ALL development.ConclusionThis study into the origins of ALL investigates the roles of transcription factors, surface markers, signaling molecules, and epigenetic modifiers in LPC proliferation and differentiation. Dysregulation of these components, often due to mutations in genes like GATA1, CRLF2, JAK2, and RAS, disrupts normal hematopoietic development and leads to leukemic transformation.

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Editorial

Abstract: EVOLUTION OF THE 2020 INTERNATIONAL SOCIETY OF LYMPHOLOGY CONSENSUS DOCUMENT PARALLELS ADVANCES IN LYMPHOLOGY: AN HISTORICAL PERSPECTIVE

Cited by 6 publications

References 0 publications

Acute Effects of Remedial Exercises with and without Compression on Breast-Cancer-Related Lymphedema

Acute Effects of Remedial Exercises with and without Compression on Breast-Cancer-Related Lymphedema

Fatigue and sleep quality improvement through complete decongestive therapy in postmastectomy lymphedema: An investigative analysis

Leukemogenesis in Acute Lymphoblastic Leukemia through the Lens of Developmental Dynamics of Lymphoid Progenitor Cells: a systematic review

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