Editorial: Updates on the pathogenesis of common variable immunodeficiency (CVID)

Martelius, Timi; Seppänen, Mikko R. J.; Warnatz, Klaus

doi:10.3389/fimmu.2022.1130418

Cited by 2 publications

(3 citation statements)

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“…The average age at diagnosis is between ages 20 and 40 years, but the condition may present in middle to late childhood and late adulthood 3. About 70% of patients presenting with CVID, including the case patient, have no genetic cause 5. Recent research findings consider CVID a combination of immune defects with innate and adaptive abnormalities 5…”

Section: Discussionmentioning

confidence: 99%

“…5 Recent research findings consider CVID a combination of immune defects with innate and adaptive abnormalities. 5 frequent being lymphoma, gastric cancer, and breast cancer. 1,10 Regular screening and monitoring for these complications based on individual disease manifestation are essential to patient care.…”

Section: Discussionmentioning

confidence: 99%

“…3 About 70% of patients presenting with CVID, including the case patient, have no genetic cause. 5 Recent research findings consider CVID a combination of immune defects with innate and adaptive abnormalities. 5 frequent being lymphoma, gastric cancer, and breast cancer.…”

Section: Discussionmentioning

confidence: 99%

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Piecing together the subtle clues of common variable immunodeficiency

Kochanoff

2023

Jaapa

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A 45-year-old woman presented to the immunology clinic with complaints of lifelong fatigue and frequent, prolonged infections often requiring antibiotics for resolution.History Ten years earlier, during a workup for an ovarian cyst, the patient had an incidental finding of scattered lymphadenopathy throughout the abdomen and pelvis on CT scan. This prompted an excisional left inguinal lymph node biopsy, which, like the ovarian cyst, was benign. She was referred to hematology/oncology and allergy/immunology for further evaluation. During these consultations, diagnostic evaluations were negative for myeloproliferative disease, hepatitis A and B, HIV, Epstein-Barr virus (EBV), and autoimmune conditions. The only abnormal finding was a low quantitative serum immunoglobulin G (IgG). No cause for lymphadenopathy or low IgG was determined.Eight years later, the patient presented to the ED with profuse vaginal bleeding and petechiae diagnosed as an acute episode of immune thrombocytopenia (ITP). ITP often is triggered by a viral infection that sets off an autoimmune

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Section: Discussionmentioning

confidence: 99%