Editorial: Transport in Plant Microbe Interactions

Courty, Pierre‐Emmanuel; Wipf, Daniel

doi:10.3389/fpls.2016.00809

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…The duo can accept a number of natural or modified aliphatic CoA starters to form the respective resorcylic acids of different side-chain lengths (e.g., C3-C6 etc.) [ 14 , 22 , 37 ]. The later pathway enzymes (prenyltransferase and cyclases) were also promiscuous enough to adopt the different side-chains, since novel cyclized cannabinoids were formed by feeding different carboxylate acid starting molecules to yeast expressing these genes [ 37 ].…”

Section: Critical Biosynthetic Steps For Phytocannabinoid Formatiomentioning

confidence: 99%

“…In addition, the non-cyclized, CBG type phytocannabinoids and cyclized, CBC-type phytocannabinoids are also reported in Rhododendron spp. (Ericaceae family) , Helichrysum umbraculigerum (Asteraceae family) , and some fungal species [ 10 , 11 , 14 , 15 ]. The sporadic discoveries of these compounds perhaps suggest a convergent evolution contributed by metabolic plasticity from the common polyketide formation/aromatic prenylation.…”

Section: Introductionmentioning

confidence: 99%

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The Biochemistry of Phytocannabinoids and Metabolic Engineering of Their Production in Heterologous Systems

Blatt-Janmaat

2021

IJMS

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The medicinal properties of cannabis and the its legal status in several countries and jurisdictions has spurred the massive growth of the cannabis economy around the globe. The value of cannabis stems from its euphoric activity offered by the unique phytocannabinoid tetrahydrocannabinol (THC). However, this is rapidly expanding beyond THC owing to other non-psychoactive phytocannabinoids with new bioactivities that will contribute to their development into clinically useful drugs. The discovery of the biosynthesis of major phytocannabinoids has allowed the exploration of their heterologous production by synthetic biology, which may lead to the industrial production of rare phytocannabinoids or novel synthetic cannabinoid pharmaceuticals that are not easily offered by cannabis plants. This review summarizes the biosynthesis of major phytocannabinoids in detail, the most recent development of their metabolic engineering in various systems, and the engineering approaches and strategies used to increase the yield.

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Section: Critical Biosynthetic Steps For Phytocannabinoid Formatiomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Biochemistry of Phytocannabinoids and Metabolic Engineering of Their Production in Heterologous Systems

Blatt-Janmaat

2021

IJMS

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“…Microbes have adapted a suite of concrete strategies with genomic basis to be competitive in a wide range of environments with spatiotemporally variable resource profiles. Many microorganisms have the potential to produce exoenzymes that can disassemble complex resources (substrate degradation), which can then be acquired through uptake (substrate uptake) via membrane transporters ( Berntsson et al, 2010 ; Arnosti 2011 ; Zimmerman et al, 2013 ; Arnostil et al, 2014 ; Courty and Wipf 2016 ; Bergauer et al, 2018 ). Thus, one aspect of resource acquisition strategy concerns the investment in both the number and diversity of exoenzymes and membrane transporters a microbe would maintain in a microbial genome.…”

Section: Resultsmentioning

confidence: 99%

microTrait: A Toolset for a Trait-Based Representation of Microbial Genomes

Karaöz

Brodie

2022

Front. Bioinform.

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Remote sensing approaches have revolutionized the study of macroorganisms, allowing theories of population and community ecology to be tested across increasingly larger scales without much compromise in resolution of biological complexity. In microbial ecology, our remote window into the ecology of microorganisms is through the lens of genome sequencing. For microbial organisms, recent evidence from genomes recovered from metagenomic samples corroborate a highly complex view of their metabolic diversity and other associated traits which map into high physiological complexity. Regardless, during the first decades of this omics era, microbial ecological research has primarily focused on taxa and functional genes as ecological units, favoring breadth of coverage over resolution of biological complexity manifested as physiological diversity. Recently, the rate at which provisional draft genomes are generated has increased substantially, giving new insights into ecological processes and interactions. From a genotype perspective, the wide availability of genome-centric data requires new data synthesis approaches that place organismal genomes center stage in the study of environmental roles and functional performance. Extraction of ecologically relevant traits from microbial genomes will be essential to the future of microbial ecological research. Here, we present microTrait, a computational pipeline that infers and distills ecologically relevant traits from microbial genome sequences. microTrait maps a genome sequence into a trait space, including discrete and continuous traits, as well as simple and composite. Traits are inferred from genes and pathways representing energetic, resource acquisition, and stress tolerance mechanisms, while genome-wide signatures are used to infer composite, or life history, traits of microorganisms. This approach is extensible to any microbial habitat, although we provide initial examples of this approach with reference to soil microbiomes.

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“…The positive effect of biofertilization with PGPRs has been demonstrated for a number of cultivars, mainly rice and wheat, and the formation of a complex biofilm structure with a microbe-plant particular interaction seems to underlie such positive effect (Courty and Wipf, 2016;Crouzet et al, 2019;Dal Cortivo et al, 2020), whereas in liquid media the biofilm structure cannot be expected to have a comparable organization level as in soil (van Gestel et al, 2015). Even though the biofertilization effect on wheat seeds using two cyanobacteria and PGPRs, either alone or in combination, was analysed here separately, the results of biometric parameters point out a major beneficial effect of cyanobacterial 2015) demonstrated using hydroponic cultures that plant accessions in Arabidopsis thaliana with positive fitness for the plant were restricted to a few specific fluorescence Pseudomonad strains, others negatively affecting plant health, with plant capability to underpin bacterial growth being a selective factor in that trait.…”

Section: Discussionmentioning

confidence: 99%