Editorial: The Role of the Basal Ganglia in Somatosensory-Motor Interactions: Evidence From Neurophysiology and Behavior

Beudel, Martijn; Macerollo, Antonella; Brown, Matt J. N.; Chen, Robert

doi:10.3389/fnhum.2019.00451

Cited by 4 publications

(6 citation statements)

References 9 publications

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“…Interestingly, each article used a unique approach (see Table 1 ) to study basal-ganglia function varying from psychophysics ( Sengupta et al ) to invasive micro-electrode recordings (MER, Filyushkina et al ). This heterogeneity of approaches is in line with the approaches described in its predecessor (Beudel et al, 2020 ).…”

supporting

confidence: 59%

Editorial: The role of the basal ganglia in somatosensory-motor interactions: evidence from neurophysiology and behavior, volume II

Beudel

Macerollo

Brown

et al. 2023

Front. Hum. Neurosci.

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supporting

confidence: 59%

Editorial: The role of the basal ganglia in somatosensory-motor interactions: evidence from neurophysiology and behavior, volume II

Beudel

Macerollo

Brown

et al. 2023

Front. Hum. Neurosci.

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“…As those studies mainly show degeneration and deficits of the peripheral nervous system in PD patients, there is also evidence for defective central integration and processing of afferent information at a cerebral level in PD. Although the basal ganglia are considered well-established primarily motor-related structures, there is conjoining clinical and experimental evidence supporting basal ganglia as active "sensory analyzers" for higher-level central somatosensory processing [69][70][71][72][73]. This is plausible, since the basal ganglia are connected to the cortex and receive input from not only motor areas but also cortical somatosensory areas [69,70].…”

Section: Plantar Cutaneous Vibration Perceptionmentioning

confidence: 99%

“…Besides results showing impairments of the peripheral nervous system, there is also evidence for the defective central integration and processing of afferent information at a cerebral level in PD patients. Although the basal ganglia are considered well-established, primarily motorrelated structures, they might also function as an active "sensory analyzer" for higher-level central somatosensory processing [69][70][71][72][73]. This is plausible, since the basal ganglia have projections into the thalamus and the cortex and receive input not only from motor areas, but also from cortical somatosensory areas, including the primary and the secondary somatosensory cortices [69,70,73,74].…”

Section: Introductionmentioning

confidence: 99%

“…Although the basal ganglia are considered well-established, primarily motorrelated structures, they might also function as an active "sensory analyzer" for higher-level central somatosensory processing [69][70][71][72][73]. This is plausible, since the basal ganglia have projections into the thalamus and the cortex and receive input not only from motor areas, but also from cortical somatosensory areas, including the primary and the secondary somatosensory cortices [69,70,73,74]. Using 3D positron emission tomography, Boecker et al showed that basal ganglia dysfunction in PD is characterized by abnormal sensory processing even for tasks devoid of any motor component [73].…”

Section: Introductionmentioning

confidence: 99%

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Does Impaired Plantar Cutaneous Vibration Perception Contribute to Axial Motor Symptoms in Parkinson’s Disease? Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation

Heß,

Themann,

Oehlwein

et al. 2023

Brain Sciences

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Objective: To investigate whether impaired plantar cutaneous vibration perception contributes to axial motor symptoms in Parkinson’s disease (PD) and whether anti-parkinsonian medication and subthalamic nucleus deep brain stimulation (STN-DBS) show different effects. Methods: Three groups were evaluated: PD patients in the medication “on” state (PD-MED), PD patients in the medication “on” state and additionally “on” STN-DBS (PD-MED–DBS), as well as healthy subjects (HS) as reference. Motor performance was analyzed using a pressure distribution platform. Plantar cutaneous vibration perception thresholds (VPT) were investigated using a customized vibration exciter at 30 Hz. Results: Motor performance of PD-MED and PD-MED–DBS was characterized by greater postural sway, smaller limits of stability ranges, and slower gait due to shorter strides, fewer steps per minute, and broader stride widths compared to HS. Comparing patient groups, PD-MED–DBS showed better overall motor performance than PD-MED, particularly for the functional limits of stability and gait. VPTs were significantly higher for PD-MED compared to those of HS, which suggests impaired plantar cutaneous vibration perception in PD. However, PD-MED–DBS showed less impaired cutaneous vibration perception than PD-MED. Conclusions: PD patients suffer from poor motor performance compared to healthy subjects. Anti-parkinsonian medication in tandem with STN-DBS seems to be superior for normalizing axial motor symptoms compared to medication alone. Plantar cutaneous vibration perception is impaired in PD patients, whereas anti-parkinsonian medication together with STN-DBS is superior for normalizing tactile cutaneous perception compared to medication alone. Consequently, based on our results and the findings of the literature, impaired plantar cutaneous vibration perception might contribute to axial motor symptoms in PD.

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“…The basal ganglia are involved in both motor and non-motor functions, including higher order cognition, social interactions, speech and repetitive behaviors [ 2 , 3 , 4 , 5 , 6 ]. The first and main clinical symptoms of diseases with basal ganglia involvement are disorders of movement and muscle tone [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging of Basal Ganglia in Neurometabolic Diseases in Children

Paprocka

Machnikowska-Sokołowska

Gruszczyńska

et al. 2020

Brain Sciences

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Diseases primarily affecting the basal ganglia in children result in characteristic disturbances of movement and muscle tone. Both experimental and clinical evidence indicates that the basal ganglia also play a role in higher mental states. The basal ganglia can be affected by neurometabolic, degenerative diseases or other conditions from which they must be differentiated. Neuroradiological findings in basal ganglia diseases are also known. However, they may be similar in different diseases. Their assessment in children may require repeated MRI examinations depending on the stage of brain development (mainly the level of myelination). A large spectrum of pathological changes in the basal ganglia in many diseases is caused by their vulnerability to metabolic abnormalities and chemical or ischemic trauma. The diagnosis is usually established by correlation of clinical and radiological findings. Neuroimaging of basal ganglia in neurometabolic diseases is helpful in early diagnosis and monitoring of changes for optimal therapy. This review focuses on neuroimaging of basal ganglia and its role in the differential diagnosis of inborn errors of metabolism.

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Editorial: The Role of the Basal Ganglia in Somatosensory-Motor Interactions: Evidence From Neurophysiology and Behavior

Cited by 4 publications

References 9 publications

Editorial: The role of the basal ganglia in somatosensory-motor interactions: evidence from neurophysiology and behavior, volume II

Editorial: The role of the basal ganglia in somatosensory-motor interactions: evidence from neurophysiology and behavior, volume II

Does Impaired Plantar Cutaneous Vibration Perception Contribute to Axial Motor Symptoms in Parkinson’s Disease? Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation

Neuroimaging of Basal Ganglia in Neurometabolic Diseases in Children

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