Editorial: T-Cell Migration in Health and Disease

Cotta-de-Almeida, Vinı́cius; Dupré, Loı̈c; Savino, Wilson

doi:10.3389/fimmu.2017.00132

Cited by 1 publication

(1 citation statement)

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“…Chemokines in the lymph node increase basal T cell motility, although they do not appear to contribute to the search strategies undertaken by T cells at the initiation of a response. Although CCR7 is required for T cells to maintain their average speed, it does not control the other features of the random walk, including the directionality (Cotta-de-Almeida et al 2017 ).…”

Section: Migration Of Immune Cells Is Central For Immune Surveillancementioning

confidence: 99%

Characterization of immune cell migration using microfabrication

Vesperini

Montalvo

et al. 2021

Biophys Rev

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The immune system provides our defense against pathogens and aberrant cells, including tumorigenic and infected cells. Motility is one of the fundamental characteristics that enable immune cells to find invading pathogens, control tissue damage, and eliminate primary developing tumors, even in the absence of external treatments. These processes are termed “immune surveillance.” Migration disorders of immune cells are related to autoimmune diseases, chronic inflammation, and tumor evasion. It is therefore essential to characterize immune cell motility in different physiologically and pathologically relevant scenarios to understand the regulatory mechanisms of functionality of immune responses. This review is focused on immune cell migration, to define the underlying mechanisms and the corresponding investigative approaches. We highlight the challenges that immune cells encounter in vivo, and the microfabrication methods to mimic particular aspects of their microenvironment. We discuss the advantages and disadvantages of the proposed tools, and provide information on how to access them. Furthermore, we summarize the directional cues that regulate individual immune cell migration, and discuss the behavior of immune cells in a complex environment composed of multiple directional cues.

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Section: Migration Of Immune Cells Is Central For Immune Surveillancementioning

confidence: 99%