Editorial: Steroids and the Brain

Ubuka, Takayoshi; Trudeau, Vance L.; Parhar, Ishwar S.

doi:10.3389/fendo.2020.00366

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Other types of hormone, steroids (e.g., testosterone, estradiol, and progesterone), control a range of social behaviors, including copulatory behavior, aggression, grooming behavior, and paternal behavior 100 , 101 . Specifically, neuroactive steroids produced in the nervous system and their receptors also play a role in the regulation of learning capacity, memory, decision-making, and depression 102 . A number of studies have demonstrated that steroid hormones also regulate lifespan; for example, the inhibition of sulfatase increases lifespan in C. elegans 103 .…”

Section: Discussionmentioning

confidence: 99%

Correlated evolution of social organization and lifespan in mammals

et al. 2023

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Discerning the relationship between sociality and longevity would permit a deeper understanding of how animal life history evolved. Here, we perform a phylogenetic comparative analysis of ~1000 mammalian species on three states of social organization (solitary, pair-living, and group-living) and longevity. We show that group-living species generally live longer than solitary species, and that the transition rate from a short-lived state to a long-lived state is higher in group-living than non-group-living species, altogether supporting the correlated evolution of social organization and longevity. The comparative brain transcriptomes of 94 mammalian species identify 31 genes, hormones and immunity-related pathways broadly involved in the association between social organization and longevity. Further selection features reveal twenty overlapping pathways under selection for both social organization and longevity. These results underscore a molecular basis for the influence of the social organization on longevity.

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Section: Discussionmentioning

confidence: 99%

Correlated evolution of social organization and lifespan in mammals

et al. 2023

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“…Females exhibit maternal care after parturition, while males who encounter pups engage in infanticide [1][2][3]. These behaviours depend on sexually dimorphic features of the brain shaped by the effects of gonadal steroid hormones [4][5][6][7] and sex chromosomes [8][9][10]. It is also proposed that epigenetic modifications, i.e., DNA methylation and histone acetylation may regulate gene expression associated with brain sexual differentiation [11].…”

Section: Introductionmentioning

confidence: 99%

Neural Contributions of the Hypothalamus to Parental Behaviour

Orikasa

2021

IJMS

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Parental behaviour is a comprehensive set of neural responses to social cues. The neural circuits that govern parental behaviour reside in several putative nuclei in the brain. Melanin concentrating hormone (MCH), a neuromodulator that integrates physiological functions, has been confirmed to be involved in parental behaviour, particularly in crouching behaviour during nursing. Abolishing MCH neurons in innate MCH knockout males promotes infanticide in virgin male mice. To understand the mechanism and function of neural networks underlying parental care and aggression against pups, it is essential to understand the basic organisation and function of the involved nuclei. This review presents newly discovered aspects of neural circuits within the hypothalamus that regulate parental behaviours.

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Neuropeptidergic control of neurosteroids biosynthesis

Ubuka¹,

Tsutsui

2022

Frontiers in Neuroendocrinology

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Editorial: Steroids and the Brain

Cited by 3 publications

References 41 publications

Correlated evolution of social organization and lifespan in mammals

Correlated evolution of social organization and lifespan in mammals

Neural Contributions of the Hypothalamus to Parental Behaviour

Neuropeptidergic control of neurosteroids biosynthesis

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