Editorial: serotonin and irritable bowel syndrome – reconciling pharmacological effects with basic biology; authors' reply

Mujagic, Zlatan; Keszthelyi, Dániel; Thijssen, Ayla; Jonkers, Daisy; Masclee, Ad

doi:10.1111/apt.13506

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Inflammatory Markers (Albumin C-reactive Protein (Crp) Calpr...1

The Serotonergic System As a Target For Treatment1

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2022

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Cited by 2 publications

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“…Data regarding the utility of CRP as a predictor of anti-TNF response are controversial. In UC, patients with lower levels of CRP seem to have a better response to IFX and ADA [78,79]; however, in other studies, there was no association [80,81]. In CD, there are many studies assessing an association between high levels of CRP and anti-TNF response [82][83][84], but others fail to find an association [8,85].…”

Section: Inflammatory Markers (Albumin C-reactive Protein (Crp) Calpr...mentioning

confidence: 99%

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Clinical Advances in Chronic Intestinal Diseases Treatment

2022

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Section: Inflammatory Markers (Albumin C-reactive Protein (Crp) Calpr...mentioning

confidence: 99%

“…Patients treated with low doses of amitriptyline (a tricyclic antidepressant) reported amelioration of all symptoms [80]. All these data suggest that SSRIs could be a useful treatment for IBS, but more clinical trials and studies are needed to clarify the controversial results [81].…”

Section: The Serotonergic System As a Target For Treatmentmentioning

confidence: 99%

Clinical Advances in Chronic Intestinal Diseases Treatment

2022

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Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management

Gros

Mesonero

et al. 2021

JCM

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Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is composed of different anatomic and functional structures intercommunicated through neurotransmitters. However, the implications of key neurotransmitters such as norepinephrine, serotonin, glutamate, GABA or acetylcholine in IBS are poorly studied. The aim of this review is to evaluate the current evidence about neurotransmitter dysfunction in IBS and explore the potential therapeutic approaches. IBS patients with altered colorectal motility show augmented norepinephrine and acetylcholine levels in plasma and an increased sensitivity of central serotonin receptors. A decrease of colonic mucosal serotonin transporter and a downregulation of α2 adrenoceptors are also correlated with visceral hypersensitivity and an increase of 5-hydroxyindole acetic acid levels, enhanced expression of high affinity choline transporter and lower levels of GABA. Given these neurotransmitter dysfunctions, novel pharmacological approaches such as 5-HT3 receptor antagonists and 5-HT4 receptor agonists are being explored for IBS management, for their antiemetic and prokinetic effects. GABA-analogous medications are being considered to reduce visceral pain. Moreover, agonists and antagonists of muscarinic receptors are under clinical trials. Targeting neurotransmitter dysfunction could provide promising new approaches for IBS management.

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Editorial: serotonin and irritable bowel syndrome – reconciling pharmacological effects with basic biology; authors' reply

Cited by 2 publications

References 12 publications

Clinical Advances in Chronic Intestinal Diseases Treatment

Clinical Advances in Chronic Intestinal Diseases Treatment

Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management

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