Editorial: Safer Use of Antipsychotics in Youth (SUAY): Should Treatment Be Guided by Symptoms?

Edelsohn, Gail A.; Abright, A. Reese

doi:10.1016/j.jaac.2021.07.009

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…As described above, the Hb is highly connected with areas responsible for the production and regulation of monoamines (e.g., dopamine and serotonin) and thus, involved in the response to standard treatments ( 1 – 5 ). However, the chronic systemic exposure to these compounds is associated with refractoriness to treatment, and may produce severe side effects that can escalate to the point of being impeditive of treatment ( 14 , 16 , 75 , 76 ). Thus, further studies are necessary to better understand the brain mechanisms associated with aggressive behaviors and develop novel treatments that are tailored to safely and effectively improve patient outcomes.…”

Section: Discussionmentioning

confidence: 99%

Habenula as a Neural Substrate for Aggressive Behavior

Gouveia

Ibrahim

2022

Front. Psychiatry

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Over the past decades, an ever growing body of literature has explored the anatomy, connections, and functions of the habenula (Hb). It has been postulated that the Hb plays a central role in the control of the monoaminergic system, thus influencing a wide range of behavioral responses, and participating in the pathophysiology of a number of psychiatric disorders and neuropsychiatric symptoms, such as aggressive behaviors. Aggressive behaviors are frequently accompanied by restlessness and agitation, and are commonly observed in patients with psychiatric disorders, intellectual disabilities, and neurodegenerative diseases of aging. Recently, the Hb has been explored as a new target for neuromodulation therapies, such as deep brain stimulation, with promising results. Here we review the anatomical organization of the habenula and discuss several distinct mechanisms by which the Hb is involved in the modulation of aggressive behaviors, and propose new investigations for the development of novel treatments targeting the habenula to reduce aggressive behaviors.

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Section: Discussionmentioning

confidence: 99%

Habenula as a Neural Substrate for Aggressive Behavior

Gouveia

Ibrahim

2022

Front. Psychiatry

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Cultural Issues in Disruptive Mood Dysregulation Disorder (DMDD) and Affective Dysregulation

Tufan,

İnal

2024

Clinician Guide to Disruptive Mood Dysregulation Disorder in Children and Adolescents

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The new psychiatric dignosis: disruptive mood dysregulation disorder

Portnova

Sivolap

2023

Neurology bulletin

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The DSM-5, adopted in 2013, presents an updated list of affective disorders, which opens with a fundamentally new psychiatric diagnosis of a disruptive mood dysregulation disorder. Disruptive mood dysregulation disorder is diagnosed in children and adolescents aged 6 to 18 years and is manifested by chronic severe and persistent irritability or anger, as well as outbursts of anger disproportionate to the cause. It is obvious that the condition of a significant part of children and adolescents with a disruptive mood dysregulation disorder before the appearance of this diagnosis was mistakenly regarded as manifestations of bipolar disorder. The criterion of the fundamental difference between disruptive mood dysregulation disorder and bipolar disorder is the absence of manic or hypomanic in the first of them. Disruptive mood dysregulation disorder is characterized by high comorbidity and is often combined with oppositional defiant disorder, conduct disorder and attention deficit with hyperactivity, as well as anxiety. The course and prognostic significance of a disruptive mood dysregulation disorder, as well as the choice of the most effective methods of pharmacological treatment and psychotherapy require numerous further studies.

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Editorial: Safer Use of Antipsychotics in Youth (SUAY): Should Treatment Be Guided by Symptoms?

Cited by 4 publications

References 8 publications

Habenula as a Neural Substrate for Aggressive Behavior

Habenula as a Neural Substrate for Aggressive Behavior

Cultural Issues in Disruptive Mood Dysregulation Disorder (DMDD) and Affective Dysregulation

The new psychiatric dignosis: disruptive mood dysregulation disorder

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