Editorial: Red Blood Cell Vascular Adhesion and Deformability

Guizouarn, Hélène; Barshtein, Gregory

doi:10.3389/fphys.2020.00657

Cited by 5 publications

(4 citation statements)

References 25 publications

(34 reference statements)

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“…Interestingly, during reticulocyte maturation, NMIIA may participate in vesicle clearance ( Moura et al, 2018 ). Because deformability concerns one of the most vital RBC attributes, allowing RBCs to pass through narrow capillaries, multiple methodologies have been used to elucidate RBC flow properties ( Artmann et al, 1997 ; Dao et al, 2003 ; Guizouarn and Barshtein, 2020 ). Indeed, elegant microfluidics approaches showed that, after repeated cycles of deformation, an experimental condition that may simulate the accumulated membrane damage during blood circulation, healthy RBCs exhibited mechanical fatigue, which led to a loss of deformability, and increased membrane shear viscosity and energy dissipation, of a magnitude that could cause dissociation of the cell membrane from its cytoskeleton ( Qiang et al, 2019 ).…”

Section: Unconventional Rbc Featuresmentioning

confidence: 99%

Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

Anastasiadi,

Arvaniti,

Hudson

et al. 2024

Protein &Amp; Cell

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Section: Unconventional Rbc Featuresmentioning

confidence: 99%

Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

Anastasiadi,

Arvaniti,

Hudson

et al. 2024

Protein &Amp; Cell

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“…Physiological and pathological changes of the body often cause changes in the number or quality (function) of blood cells, and then lead to anemia, fever, infection, bleeding and vascular embolism and other clinical symptoms, and seriously affect the communication of information and material transfer between cells 22 , 23 . In the microvascular system, when red blood cells flow through narrow capillaries, due to shear stress, red blood cells will undergo compression and deformation in capillaries, thus promoting material exchange between red blood cells and surrounding tissues 24 , 25 . In tumor micro-environment (TME), neutrophils release cytokines and other special messengers to enhance the ability of tumor cells to metastasize 26 .…”

Section: Morphology Deformation-based Cellular Carriersmentioning

confidence: 99%

Natural cell based biomimetic cellular transformers for targeted therapy of digestive system cancer

Tang¹,

Li²,

Gu³

et al. 2022

Theranostics

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Digestive system cancer is the most common cause of cancer death in the world. Although cancer treatment options are increasingly diversified, the mortality rate of malignant cancer of the digestive system remains high. Therefore, it is necessary to explore effective cancer treatment methods. Recently, biomimetic nanoparticle delivery systems based on natural cells that organically integrate the low immunogenicity, high biocompatibility, cancer targeting, and controllable, versatile functionality of smart nanocarrier design with natural cells have been expected to break through the bottleneck of tumor targeted therapy. In this review, we focus on the dynamic changes and complex cellular communications that occur in vivo in natural cells based vehicles. Recent studies on the development of advanced targeted drug delivery systems using the dynamic behaviors such as specific surface protein affinity, morphological changes, and phenotypic polarization of natural cells are summarized. In addition to drug delivery mediated by dynamic behavior, functional “delivery” based on the natural cell themselves is also involved. Aiming to make the best use of the functions of cells, providing clues for the development of advanced drug delivery platforms.

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“…Due to the storage lesions, the perfusion and the oxygen delivery in peripheral tissues are impaired, contributing to poor survival of transfused RBCs and increased morbidity and mortality [6,7]. Changes in the mechanical properties include a decrease in deformability [8] which is regarded as a sensitive indicator of RBC reduced functionality [9], increased rigidity [10,11], increased intracellular viscosity [12,13], as a result of a decreased surface area to volume ratio of the RBCs [14]. In addition, increased aggregability [15], adherence [16], and hemolysis during the shelf life were also reported [17].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic testing of the biomechanical properties of donation blood

Mohamed

Pomarède

Mangin

et al. 2023

Biomed. Phys. Eng. Express

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Background: Donated blood is routinely preserved for about six weeks. After that, a considerable amount of unused blood is discarded for safety. We carried out sequential measurements of the ultrasonic parameters (Velocity of propagation of ultrasound, its attenuation, and relative nonlinearity coefficient B/A) for red blood cell (RBCs) bags in their physiological preserving conditions in the blood bank to investigate the gradual deteriorations in the biomechanical properties of RBCs. Materials and Methods: We discuss our primary findings, which indicate the applicability of ultrasound techniques as a quantitative quick, non-invasive routine check for the validity of sealed blood bags. The technique can be applied during and beyond the regular preservation period, thus enabling deciding for each bag to either further preserve or withdraw. Results and Discussion: Considerable increases in the velocity of propagation (V = 966 m/s) and ultrasound attenuation ( = 0.81dB/Cm) were detected to take place during the preservation time. Likewise, the relative nonlinearity coefficient showed a generally rising trend during the preservation period ( (B/A) = 0.0129). At the same time, a distinctive feature characteristic of a specific blood group type is realized in all cases.Due to the complex stress-strain relations and their reflection on the hydrodynamics and flow rate of non-Newtonian fluids, the increased viscosity of long-preserved blood may justify the known post-transfusion flow complications.

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Editorial: Red Blood Cell Vascular Adhesion and Deformability

Cited by 5 publications

References 25 publications

Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

Natural cell based biomimetic cellular transformers for targeted therapy of digestive system cancer

Ultrasonic testing of the biomechanical properties of donation blood

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