Editorial: Recent Advances in Potential Biomarkers for Rheumatic Diseases and in Cell-Based Therapies in the Management of Inflammatory Rheumatic Diseases

Saas, Philippe; Toussirot, Éric; Bogunia‐Kubik, Katarzyna

doi:10.3389/fimmu.2021.836119

Cited by 6 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, some patients develop undesirable side effects, such as infections. Thus, new therapies are still needed in RA ( 2 ). Our encouraging results obtained with SuperMApo in CIA support its use in RA.…”

Section: Discussionmentioning

confidence: 99%

“…Although these chronic inflammatory disorders result from various pathogenic mechanisms, they share this non-resolving inflammation ( 1 ). Nevertheless, these chronic diseases are not always controlled by current treatments and development of new therapeutic approaches is urgently required (as recently discussed in an editorial on inflammatory rheumatic diseases ( 2 )).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation

Saas

Vetter²,

Maraux³

et al. 2022

Front. Immunol.

Self Cite

View full text Add to dashboard Cite

Several chronic inflammatory diseases are associated with non-resolving inflammation. Conventional anti-inflammatory drugs fail to completely cure these diseases. Resolution pharmacology is a new therapeutic approach based on the use of pro-resolving mediators that accelerate the resolution phase of inflammation by targeting the productive phase of inflammation. Indeed, pro-resolving mediators prevent leukocyte recruitment and induce apoptosis of accumulated leukocytes. This approach is now called resolution therapy with the introduction of complex biological drugs and cell-based therapies. The main objective of resolution therapy is to specifically reduce the duration of the resolution phase to accelerate the return to homeostasis. Under physiological conditions, macrophages play a critical role in the resolution of inflammation. Indeed, after the removal of apoptotic cells (a process called efferocytosis), macrophages display anti-inflammatory reprogramming and subsequently secrete multiple pro-resolving factors. These factors can be used as resolution therapy. Here, we review the different mechanisms leading to anti-inflammatory reprogramming of macrophages after efferocytosis and the pro-resolving factors released by these efferocytic macrophages. We classify these mechanisms in three different categories: macrophage reprogramming induced by apoptotic cell-derived factors, by molecules expressed by apoptotic cells (i.e., “eat-me” signals), and induced by the digestion of apoptotic cell-derived materials. We also evoke that macrophage reprogramming may result from cooperative mechanisms, for instance, implicating the apoptotic cell-induced microenvironment (including cellular metabolites, specific cytokines or immune cells). Then, we describe a new drug candidate belonging to this resolution therapy. This candidate, called SuperMApo, corresponds to the secretome of efferocytic macrophages. We discuss its production, the pro-resolving factors present in this drug, as well as the results obtained in experimental models of chronic (e.g., arthritis, colitis) and acute (e.g., peritonitis or xenogeneic graft-versus-host disease) inflammatory diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation

Saas

Vetter²,

Maraux³

et al. 2022

Front. Immunol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Inflammatory rheumatic diseases (IRD) encompass a diverse group of autoimmune conditions characterized by chronicity and heterogeneity [ 55 ]. IRD is an umbrella term for a wide range of conditions that include disorders of connective tissue (e.g., systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis) and inflammatory arthropathies (e.g., psoriatic arthritis, axial spondyloarthritis, rheumatoid arthritis) [ 56 ]. The pathogenesis of IRD remains unclear due to its complex and variable character.…”

Section: Aim Of the Articlementioning

confidence: 99%

Potential role of camel, mare milk, and their products in inflammatory rheumatic diseases

Kocyigit,

Abdurakhmanov,

Kocyigit

2024

Rheumatol Int

View full text Add to dashboard Cite

Milk and dairy products serve as a significant dietary component for people all over the world. Milk is a source of essential nutrients such as carbohydrates, protein, fats, and water that support newborns' growth, development, and physiological processes. Milk contains various essential biological compounds that contribute to overall health and well-being. These compounds are crucial in immune system regulation, bone health, and gut microbiota. Milk and dairy products are primarily from cows, buffalos, goats, and sheep. Recently, there has been a notable increase in camel and mare milk consumption and its associated products due to an increasing attraction to ethnic cuisines and a greater awareness of food biodiversity. Camel and mare milk possess diverse nutritional and therapeutic properties, displaying potential functional foods. Camel milk has been linked to various health advantages, encompassing antihypertensive, antidiabetic, antiallergic, anticarcinogenic, antioxidant, and immunomodulatory properties. Camel milk has exhibited notable efficacy in mitigating inflammation and oxidative stress, potentially offering therapeutic benefits for inflammatory disorders. Nevertheless, although extensively recorded, the potential health benefits of mare's milk have yet to be investigated, including its impact on inflammatory conditions. This article highlights the therapeutic potential of camel and mare milk and its derived products in treating inflammatory rheumatic disorders, specifically focusing on their anti-inflammatory and immune-regulatory capabilities. These alternative types of milk, which do not come from cows, offer potential avenues for investigating innovative strategies to regulate and reduce inflammatory conditions.

show abstract

“…It also contains vasculitis and connective tissue disorders, like Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). This highly heterogeneous group of disorders was characterized by persistent systemic inflammation mainly affecting the musculoskeletal system and connective tissue (8)(9)(10). Previous studies have demonstrated that IRDs were associated with an increased risk of dementia, depressive disorders, and stroke (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory rheumatic diseases and the risk of Parkinson's disease: A systematic review and meta-analysis

McClements

Zhao²,

Wang³

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

BackgroundSeveral studies showed inconsistencies in the relationships between inflammatory rheumatic diseases (IRDs) and the risk of Parkinson's disease (PD). Therefore, we carried out a meta-analysis to investigate the associations between different IRDs and PD risk.MethodsA comprehensive search was undertaken on PubMed, Embase, Cochrane Library, and Web of Science databases up to June 2022. Studies reporting the relationships between IRDs and PD risk were included. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated by using random-effects models.ResultsTwenty-two publications covering seven IRDs containing data from 833,004 patients were identified for quantitative analysis. The pooled results indicated that ankylosing spondylitis (RR = 1.55, 95% CI: 1.31–1.83, I2 = 32.1%, P < 0.001), Sjögren's syndrome (RR = 1.34, 95% CI: 1.22–1.47, I2 = 58.5%, P < 0.001), and Behcet's disease (RR = 1.93, 95% CI: 1.07–3.49, I2 = 57.6%, P = 0.030) were associated with an increased PD risk. However, no significant associations were observed between gout, rheumatoid arthritis, systemic lupus erythematosus, as well as polymyalgia rheumatica and the subsequent development of PD.ConclusionAnkylosing spondylitis, Sjögren's syndrome, and Behcet's disease may increase PD risk.

show abstract

Editorial: Recent Advances in Potential Biomarkers for Rheumatic Diseases and in Cell-Based Therapies in the Management of Inflammatory Rheumatic Diseases

Cited by 6 publications

References 11 publications

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation

Potential role of camel, mare milk, and their products in inflammatory rheumatic diseases

Inflammatory rheumatic diseases and the risk of Parkinson's disease: A systematic review and meta-analysis

Contact Info

Product

Resources

About