Editorial: Novel Therapeutic Approaches in Inflammatory Bowel Diseases

Pallio, Giovanni

doi:10.3390/biomedicines11092466

Biomedicines

2023

DOI: 10.3390/biomedicines11092466

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Editorial: Novel Therapeutic Approaches in Inflammatory Bowel Diseases

Giovanni Pallio

Abstract: Inflammatory bowel diseases (IBDs) encompass ulcerative colitis (UC) and Crohn’s disease (CD), both of which are inflammatory ailments affecting the gastrointestinal tract [...]

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The nutritional function of active polysaccharides from marine animals: A review

Guan,

Wang,

Zhou

et al. 2024

Food Bioscience

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Therapeutic role of extracellular vesicles from human umbilical cord mesenchymal stem cells and their wide therapeutic implications in inflammatory bowel disease and other inflammatory disorder

Din,

Wan,

Chu

et al. 2024

Front. Med.

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The chronic immune-mediated inflammatory condition known as inflammatory bowel disease (IBD) significantly affects the gastrointestinal system. While the precise etiology of IBD remains elusive, extensive research suggests that a range of pathophysiological pathways and immunopathological mechanisms may significantly contribute as potential factors. Mesenchymal stem cells (MSCs) have shown significant potential in the development of novel therapeutic approaches for various medical conditions. However, some MSCs have been found to exhibit tumorigenic characteristics, which limit their potential for medical treatments. The extracellular vesicles (EVs), paracrine factors play a crucial role in the therapeutic benefits conferred by MSCs. The EVs consist of proteins, microRNAs, and lipids, and are instrumental in facilitating intercellular communication. Due to the ease of maintenance, and decreased immunogenicity, tumorigenicity the EVs have become a new and exciting option for whole cell treatment. This review comprehensively assesses recent preclinical research on human umbilical cord mesenchymal stem cell (hUC-MSC)-derived EVs as a potential IBD therapy. It comprehensively addresses key aspects of various conditions, including diabetes, cancer, dermal injuries, neurological disorders, cardiovascular issues, liver and kidney diseases, and bone-related afflictions.

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Editorial: Novel Therapeutic Approaches in Inflammatory Bowel Diseases

Abstract: Inflammatory bowel diseases (IBDs) encompass ulcerative colitis (UC) and Crohn’s disease (CD), both of which are inflammatory ailments affecting the gastrointestinal tract [...]

Cited by 2 publications

References 24 publications

The nutritional function of active polysaccharides from marine animals: A review

The nutritional function of active polysaccharides from marine animals: A review

Therapeutic role of extracellular vesicles from human umbilical cord mesenchymal stem cells and their wide therapeutic implications in inflammatory bowel disease and other inflammatory disorder

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